Drug Surfactant and Polymer Mediated Acid Catalyzed Hydrolysis of Acetohydroxamic Acid

被引：0

作者：

Sar, Santosh K. ^{[1
]}

Soni, Pankaj ^{[1
]}

机构：

[1] Bhilai Inst Technol, Dept Chem Engn, Ctr Environm Sci & Engn, Durg 491002, CG, India

来源：

JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2010年 / 31卷 / 09期

关键词：

Acetohydroxmic acid; acid-hydrolysis; amitriptyline (AMYTP plus ) polymer-surfactant; tri-cyclic antidepressant-drug; HYDROXAMIC ACIDS;

D O I：

10.1080/01932690903223559

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The effects of drug-surfactant and polymer on the acid hydrolysis of acetohydroxamic acid (AHA) have been studied at room temperature in 2% (v/v) dioxane medium. Kinetic data corresponding to the reaction with drug micelles are analyzed by using the pseudo-phase ion exchange model. The binding constant and first-order rate constant in micellar media in presence of AMYTP+-Drug, AMYTP+--Cyclodextrine, AMYTP+-SDS, AMYTP+-PEG, AMYTP+-TX-100, AMYTP+-CTAB, have been studied in 0.5M HCl media.

引用

页码：1163 / 1166

页数：4

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