Analysis of estrogen receptor a signaling complex at the plasma membrane

被引：0

作者：

Azuma, K ^{[1
]}

Horie, K ^{[1
]}

Inoue, S ^{[1
]}

Ouchi, Y ^{[1
]}

Sakai, R ^{[1
]}

机构：

[1] Natl Canc Ctr, Res Inst, Div Growth Factor, Chuo Ku, Tokyo 1040045, Japan

来源：

PROCEEDINGS OF THE 12TH INTERNATIONAL CONGRESS OF ENDOCRINOLOGY | 2004年

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is accumulating evidence that the estrogen receptor (ER) can transduce specific signals at the plasma membrane. We tried to clarify the biological function of ER as a signaling molecule by identifying proteins that interact with the membrane-localized ER. The AF-1 and AF-2 domains of ER alpha with or without the membrane-targeting sequence were stably expressed in the breast cancer cell line, MCF-7. alpha- and beta-tubulins and heat shock protein 70 were identified as the AF-1-associated proteins. Of these, tubulins are associated only with membrane-targeted AF-1.

引用

页码：507 / 510

页数：4

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