The Action-Networks of Nanosilver: Bridging the Gap between Material and Biology

被引：8

作者：

Cao, Huiliang ^{[1
,2
,3
]}

Qin, Hui ^{[4
]}

Li, Yongsheng ^{[1
,2
]}

Jandt, Klaus D. ^{[3
,5
,6
]}

机构：

[1] East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Lab Low Dimens Mat Chem, Shanghai 200237, Peoples R China

[2] East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Engn Res Ctr Hierarch Nanomat, Shanghai 200237, Peoples R China

[3] Friedrich Schiller Univ Jena, Otto Schott Inst Mat Res, Chair Mat Sci, D-07743 Jena, Germany

[4] Shanghai Jiaotong Univ Affiliated Peoples Hosp 6, Dept Orthopaed, Shanghai 200233, Peoples R China

[5] Friedrich Schiller Univ Jena, Jena Ctr Soft Matter JCSM, D-07743 Jena, Germany

[6] Jena Sch Microbial Commun JSMC, Neugasse 23, D-07743 Jena, Germany

来源：

ADVANCED HEALTHCARE MATERIALS | 2021年 / 10卷 / 18期

基金：

中国国家自然科学基金;

关键词：

antimicrobials; implantable medical devices; nanobiology; nanomedicine; nanosafety; COATED SILVER NANOPARTICLES; ENHANCED ANTIMICROBIAL ACTIVITY; MICROWAVE-ASSISTED SYNTHESIS; IN-VIVO GENOTOXICITY; ANTIBACTERIAL ACTIVITY; NANO-SILVER; GOLD NANOPARTICLES; OPTICAL-PROPERTIES; ION-IMPLANTATION; GREEN SYNTHESIS;

D O I：

10.1002/adhm.202100619

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The emergence of nanosilver (silver in nanoscale shapes and their assemblies) benefits the landscape of modern healthcare; however, this brings about concerns over its safety issues associated with an ultrasmall size and high mobility. By reviewing previous reporting details about the synthesis and characterization of nanosilver and its biological responses, a gap between materials synthesis and their biomedical uses is characterized by the insufficient understanding of the interacting and interplaying nanoscale actions of silver. To improve reporting quality and advance clinical translations, it is suggested that researchers have a comprehensive recognition of the "Indications for use" before designing innovative nanosilver-based materials and an "Action-network" concept addressing the acting range and strength of those nanoscale actions is implemented. Although this discussion is specific to nanosilver, the idea of "Indications for use" centered design and synthesis is generally applicable to other biomedical nanomaterials.

引用

页数：28

共 276 条

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