Circular RNA expression and function in the brain

被引：46

作者：

Sekar, Shobana ^{[1
]}

Liang, Winnie S. ^{[1
]}

机构：

[1] Translat Genom Res Inst, Phoenix, AZ USA

来源：

NON-CODING RNA RESEARCH | 2019年 / 4卷 / 01期

基金：

美国国家卫生研究院;

关键词：

circRNA; Non-coding RNA; Brain; Transcriptional regulation; Neurological disease; microRNA; BLOOD MONONUCLEAR-CELLS; PERIPHERAL-BLOOD; DIAGNOSTIC BIOMARKER; BARRIER; IDENTIFICATION; BIOGENESIS; REVEALS; DISEASE; PROFILE; TRANSCRIPTOME;

D O I：

10.1016/j.ncrna.2019.01.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Within the last decade, active research on circular RNAs (circRNAs) has dramatically improved our understanding of the expression and function of these non-coding RNAs. While several mechanisms for circRNA function have been proposed, including sequestration of microRNAs and regulation of cellular proteins, studies provide evidence that circRNAs can regulate transcription and may also serve as biomarkers. Due to the heterogeneous nature of the brain, and the dynamic transcriptional mechanisms that support neurobiological pathways, the influence of circRNAs is potentially extensive. Understanding how circRNAs contribute to key neurological pathways will fill gaps in our understanding of brain function and provide valuable insight into novel therapeutic approaches to treat neurological diseases. Here, we review recent research on circRNA expression in the brain, describe the proposed functions of circRNAs, and evaluate the role of circRNAs in neurological diseases.

引用

页码：23 / 29

页数：7

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