Expeditious Access to Functionalized Tricyclic Pyrrolo-Pyridones via Tandem or Sequential C-N/C-C Bond Formations

被引：9
|
作者：
Fillery, Shaun M. [1 ]
Gregson, Clare L. [1 ]
Guerot, Carine M. [1 ]
机构：
[1] AstraZeneca, Med Chem, Oncol R&D, Cambridge, England
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 22期
关键词：
INHIBITORS; ANNULATION; ALKALOIDS; ALKYNES; POTENT;
D O I：
10.1021/acs.orglett.9b03514
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The facile synthesis of both saturated and unsaturated tricyclic pyrrolo-pyridones starting from a single readily available, common monocyclic reagent has been developed. An intermolecular annulation via a tandem Buchwald-Hartwig/Heck reaction led to the synthesis of beta-carbolinones. The analogous semisaturated tricyclic pyrrolo-pyridones were prepared in good to excellent yields by sequential Buchwald-Hartwig and Fischer indole reactions. The methods feature mild reaction conditions and good functional group tolerance.
引用
收藏
页码：9128 / 9132
页数：5
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