Expeditious Access to Functionalized Tricyclic Pyrrolo-Pyridones via Tandem or Sequential C-N/C-C Bond Formations

被引：9

作者：

Fillery, Shaun M. ^{[1
]}

Gregson, Clare L. ^{[1
]}

Guerot, Carine M. ^{[1
]}

机构：

[1] AstraZeneca, Med Chem, Oncol R&D, Cambridge, England

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 22期

关键词：

INHIBITORS; ANNULATION; ALKALOIDS; ALKYNES; POTENT;

D O I：

10.1021/acs.orglett.9b03514

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The facile synthesis of both saturated and unsaturated tricyclic pyrrolo-pyridones starting from a single readily available, common monocyclic reagent has been developed. An intermolecular annulation via a tandem Buchwald-Hartwig/Heck reaction led to the synthesis of beta-carbolinones. The analogous semisaturated tricyclic pyrrolo-pyridones were prepared in good to excellent yields by sequential Buchwald-Hartwig and Fischer indole reactions. The methods feature mild reaction conditions and good functional group tolerance.

引用

页码：9128 / 9132

页数：5

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