Development of a stick-type transdermal eyelid delivery system of ketotifen fumarate for ophthalmic diseases

被引：11
作者：
Kimura, Chiharu [1 ]
Tojo, Kakuji [1 ]
机构：
[1] Kyushu Inst Technol, Coll Comp Sci & Syst Engn, Iizuka, Fukuoka 8208502, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2007年 / 55卷 / 07期
关键词：
eye-stick; transdermal delivery system; ketotifen fumarate; eyelid; eye drop;
D O I：
10.1248/cpb.55.1002
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A transdermal eyelid delivery system for treating ocular diseases (eye-stick) has been developed. Ketotifen fumarate (KT) was used as a model drug. An in vivo study using rabbits showed that the eye-stick device maintained a constant conjunctival concentration of the drug for an extended period of time, which was equivalent or higher than the therapeutic level following eye drop administration. Moreover, the conjunctival concentration after eye-stick application was well predicted using the physicochemical parameters, diffusion coefficient and partition coefficient, obtained from in vitro hairless mouse skin permeation experiments.
引用
收藏
页码：1002 / 1005
页数：4
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