Sonoporation, anti-cancer drug and antibody delivery using ultrasound

被引：71

作者：

Wu, Junru ^{[1
]}

Pepe, Jason

Rincon, Mercedes

机构：

[1] Univ Vermont, Dept Phys, Burlington, VT 05405 USA

[2] Univ Vermont, Dept Med, Burlington, VT 05405 USA

来源：

ULTRASONICS | 2006年 / 44卷

关键词：

bioacoustics; biomedical ultrasound; sonoporation; gene therapy; DNA; antibodies; anti-cancer drug; drug delivery;

D O I：

10.1016/j.ultras.2006.06.033

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

It has been shown experimentally in cell suspensions that sonoporation could be used to deliver the anti- cancer drug Adriamycin hydrochloride ( ADR) into Jurkat lymphocytes and that it could also be used to deliver goat anti- rabbit IgG and anti- mouse IgD, antibodies into human peripheral blood mononuclear cells ( PBMC) and Jurkat lymphocytes. When ADR was delivered, the delivery efficiency reached 4.80 +/- 2.04% and control baseline ( no ultrasound and no ADR) was 0.17 +/- 0.14%. When anti- rabbit IgD was delivered, the efficiencies were 34.90 +/- 1.80% ( control baseline was 1.33 +/- 0.31%) and 32.50 +/- 4.36% ( control baseline was 1.66 +/- 0.06%) respectively for Jurkat cells and PBMC. When goat anti- rabbit IgG was delivered, the efficiencies were 78.60 +/- 3.60% (control baseline was 1.60 +/- 0.00%) and 57.50 +/- 4.23% ( control baseline was 11.30 +/- 0.81%) respectively for Jurkat cells and PBMC. (c) 2006 Elsevier B. V. All rights reserved.

引用

页码：E21 / E25

页数：5