A Mouse Model of Zika Virus Pathogenesis

被引：726
作者：
Lazear, Helen M. [1 ]
Govero, Jennifer [2 ]
Smith, Amber M. [2 ]
Platt, Derek J. [2 ]
Fernandez, Estefania [2 ]
Miner, Jonathan J. [2 ]
Diamond, Michael S. [2 ,3 ,4 ,5 ]
机构：
[1] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA
[2] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
[4] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
[5] Washington Univ, Sch Med, Ctr Human Immunol & Immunotherapy Programs, St Louis, MO 63110 USA
来源：
CELL HOST & MICROBE | 2016年 / 19卷 / 05期
关键词：
UNITED-STATES; ALPHA/BETA; TRANSMISSION; INFECTION; ISOLATIONS; OUTBREAK; PROTEIN; BRAZIL; ROLES; BRAIN;
D O I：
10.1016/j.chom.2016.03.010
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The ongoing Zika virus (ZIKV) epidemic and unexpected clinical outcomes, including Guillain-Barre syndrome and birth defects, has brought an urgent need for animal models. We evaluated infection and pathogenesis with contemporary and historical ZIKV strains in immunocompetent mice and mice lacking components of the antiviral response. Four-to six-week-old Irf3(-/-) Irf5(-/-) Irf7(-/-) triple knockout mice, which produce little interferon alpha/beta, and mice lacking the interferon receptor (Ifnar1(-/-)) developed neurological disease and succumbed to ZIKV infection, whereas single Irf3(-/-), Irf5(-/-), and Mavs(-/-) knockout mice exhibited no overt illness. Ifnar1(-/-) mice sustained high viral loads in the brain and spinal cord, consistent with evidence that ZIKV causes neurodevelopmental defects in human fetuses. The testes of Ifnar1(-/-) mice had the highest viral loads, which is relevant to sexual transmission of ZIKV. This model of ZIKV pathogenesis will be valuable for evaluating vaccines and therapeutics as well as understanding disease pathogenesis.
引用
收藏
页码：720 / 730
页数：11
相关论文
共 67 条
  • [51] Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-α/β gene induction
    Sato, M
    Suemori, H
    Hata, N
    Asagiri, M
    Ogasawara, K
    Nakao, K
    Nakaya, T
    Katsuki, M
    Noguchi, S
    Tanaka, N
    Taniguchi, T
    [J]. IMMUNITY, 2000, 13 (04) : 539 - 548
  • [52] The N-Ethyl-N-Nitrosourea-Induced Goldenticket Mouse Mutant Reveals an Essential Function of Sting in the In Vivo Interferon Response to Listeria monocytogenes and Cyclic Dinucleotides
    Sauer, John-Demian
    Sotelo-Troha, Katia
    von Moltke, Jakob
    Monroe, Kathryn M.
    Rae, Chris S.
    Brubaker, Sky W.
    Hyodo, Mamoru
    Hayakawa, Yoshihiro
    Woodward, Joshua J.
    Portnoy, Daniel A.
    Vance, Russell E.
    [J]. INFECTION AND IMMUNITY, 2011, 79 (02) : 688 - 694
  • [53] Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity
    Schoggins, John W.
    MacDuff, Donna A.
    Imanaka, Naoko
    Gainey, Maria D.
    Shrestha, Bimmi
    Eitson, Jennifer L.
    Mar, Katrina B.
    Richardson, R. Blake
    Ratushny, Alexander V.
    Litvak, Vladimir
    Dabelic, Rea
    Manicassamy, Balaji
    Aitchison, John D.
    Aderem, Alan
    Elliott, Richard M.
    Garcia-Sastre, Adolfo
    Racaniello, Vincent
    Snijder, Eric J.
    Yokoyama, Wayne M.
    Diamond, Michael S.
    Virgin, Herbert W.
    Rice, Charles M.
    [J]. NATURE, 2014, 505 (7485) : 691 - +
  • [54] Blocking monoclonal antibodies specific for mouse IFN-α/β receptor subunit 1 (IFNAR-1) from mice immunized by in vivo hydrodynamic transfection
    Sheehan, Kathleen C. F.
    Lai, Koon Siew
    Dunn, Gavin P.
    Bruce, Allen T.
    Diamond, Mark S.
    Heutel, Jennifer D.
    Dungo-Arthur, Corazon
    Carrero, Javier A.
    White, J. Michael
    Hertzog, Paul J.
    Schreiber, Robert D.
    [J]. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2006, 26 (11) : 804 - 819
  • [55] Selective Blockade of Interferon-α and -β Reveals Their Non-Redundant Functions in a Mouse Model of West Nile Virus Infection
    Sheehan, Kathleen C. F.
    Lazear, Helen M.
    Diamond, Michael S.
    Schreiber, Robert D.
    [J]. PLOS ONE, 2015, 10 (05):
  • [56] Dengue virus replication in infected human keratinocytes leads to activation of antiviral innate immune responses
    Surasombatpattana, Pornapat
    Hamel, Rodolphe
    Patramool, Sirilaksana
    Luplertlop, Natthanej
    Thomas, Frederic
    Despres, Philippe
    Briant, Laurence
    Yssel, Hans
    Misse, Dorothee
    [J]. INFECTION GENETICS AND EVOLUTION, 2011, 11 (07) : 1664 - 1673
  • [57] Innate Immune Sensing of Flaviviruses
    Suthar, Mehul S.
    Aguirre, Sebastian
    Fernandez-Sesma, Ana
    [J]. PLOS PATHOGENS, 2013, 9 (09)
  • [58] IPS-1 Is Essential for the Control of West Nile Virus Infection and Immunity
    Suthar, Mehul S.
    Ma, Daphne Y.
    Thomas, Sunil
    Lund, Jennifer M.
    Zhang, Nu
    Daffis, Stephane
    Rudensky, Alexander Y.
    Bevan, Michael J.
    Clark, Edward A.
    Kaja, Murali-Krishna
    Diamond, Michael S.
    Gale, Michael, Jr.
    [J]. PLOS PATHOGENS, 2010, 6 (02)
  • [59] 2′-O Methylation of the Viral mRNA Cap by West Nile Virus Evades Ifit1-Dependent and -Independent Mechanisms of Host Restriction In Vivo
    Szretter, Kristy J.
    Daniels, Brian P.
    Cho, Hyelim
    Gainey, Maria D.
    Yokoyama, Wayne M.
    Gale, Michael, Jr.
    Virgin, Herbert W.
    Klein, Robyn S.
    Sen, Ganes C.
    Diamond, Michael S.
    [J]. PLOS PATHOGENS, 2012, 8 (05)
  • [60] Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors
    Takaoka, A
    Yanai, H
    Kondo, S
    Duncan, G
    Negishi, H
    Mizutani, T
    Kano, S
    Honda, K
    Ohba, Y
    Mak, TW
    Taniguchi, T
    [J]. NATURE, 2005, 434 (7030) : 243 - 249
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