Resistin: molecular history and prognosis

被引：112
作者：
Banerjee, RR [1 ]
Lazar, MA [1 ]
机构：
[1] Univ Penn, Sch Med, Ctr Diabet, Div Endocrinol Diabet & Metab, Philadelphia, PA 19104 USA
来源：
JOURNAL OF MOLECULAR MEDICINE-JMM | 2003年 / 81卷 / 04期
关键词：
resistin; obesity; type; 2; diabetes; insulin resistance; thiazolidinediones;
D O I：
10.1007/s00109-003-0428-9
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Obesity and diabetes have reached epidemic proportions worldwide. The antidiabetic thiazolidinedione (TZD) drugs are insulin-sensitizing agents now widely used in the treatment of type 2 diabetes. TZDs are ligands for the nuclear hormone receptor peroxisome proliferator activated receptor gamma, which is a master regulator of adipogenesis and adipocyte metabolism. The molecular mechanisms by which TZDs improve insulin sensitivity have not been fully identified. Here we consider a novel secreted factor first identified as a TZD-suppressible gene in mouse adipocytes, called resistin, and discuss what is currently known about resistin regulation and function in mouse and human.
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收藏
页码：218 / 226
页数：9
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