Human serum albumin as an intrinsic signal amplification amplifier for ultrasensitive assays of the prostate-specific antigen in human plasma

被引：13
作者：
Yang, Le [1 ]
Zheng, Jing [1 ]
Zou, Zhen [2 ]
Cai, Haiyan [3 ]
Qi, Peng [2 ]
Qing, Zhihe [2 ]
Yan, Qi [2 ]
Qiu, Liping [1 ]
Tan, Weihong [1 ]
Yang, Ronghua [1 ,2 ]
机构：
[1] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410114, Peoples R China
[2] Changsha Univ Sci & Technol, Sch Chem & Food Engn, Changsha 410082, Peoples R China
[3] Shanghai Jiao Tong Univ, Minist Educ, Key Lab Cell Differentiat & Apoptosis Chinese, Sch Med,Dept Pathophysiol, Shanghai 200240, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 12期
基金：
中国国家自然科学基金;
关键词：
DNA; IMMUNOASSAY; BINDING; CANCER; NANOPARTICLES; ACID;
D O I：
10.1039/c9cc08501g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
As the most abundant protein in blood, human serum albumin (HSA) is usually regarded as an interferent in clinical molecular diagnosis. Herein, we report that HSA is an endogenous signal amplifier for the detection of the prostate-specific antigen (PSA) in human plasma. This is the first study to utilize intrinsic biological components as the signal amplifier in blood tests.
引用
收藏
页码：1843 / 1846
页数：4
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