Role of Viral miRNAs and Epigenetic Modifications in Epstein-Barr Virus-Associated Gastric Carcinogenesis

被引：27

作者：

Giudice, Aldo ^{[1
]}

D'Arena, Giovanni ^{[2
]}

Crispo, Anna ^{[1
]}

Tecce, Mario Felice ^{[3
]}

Nocerino, Flavia ^{[1
]}

Grimaldi, Maria ^{[1
]}

Rotondo, Emanuela ^{[1
]}

D'Ursi, Anna Maria ^{[3
]}

Scrima, Mario ^{[3
]}

Galdiero, Massimiliano ^{[4
]}

Ciliberto, Gennaro ^{[5
]}

Capunzo, Mario ^{[6
]}

Franci, Gianluigi ^{[4
]}

Barbieri, Antonio ^{[7
]}

Bimonte, Sabrina ^{[8
]}

Montella, Maurizio ^{[1
]}

机构：

[1] IRCCS, G Pascale Fdn, Natl Canc Inst Naples, Epidemiol Unit, I-80131 Naples, Italy

[2] Canc Referral Ctr Basilicata, IRCCS, Dept Oncohematol, I-85028 Rionero In Vulture, Italy

[3] Univ Salerno, Dept Pharm, I-84084 Salerno, Italy

[4] Univ Naples Federico II, Dept Expt Med 2, I-81055 Naples, Italy

[5] IRCCS, G Pascale Fdn, Natl Canc Inst, Sci Direct, I-80131 Naples, Italy

[6] Univ Salerno, Dept Med & Surg, I-84081 Salerno, Italy

[7] IRCCS, G Pascale Fdn, Natl Canc Inst Naples, Anim Facil Unit, I-80131 Naples, Italy

[8] IRCCS, G Pascale Fdn, Natl Canc Inst, Div Abdominal Surg Oncol,Hepatobiliary Unit, I-80131 Naples, Italy

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2016年 / 2016卷

关键词：

ISLAND METHYLATOR PHENOTYPE; DNA METHYLATION; CONSTITUTIVE ACTIVATION; RETROVIRAL MICRORNAS; CELL-DIFFERENTIATION; HERPESVIRUS USES; DOWN-REGULATION; NONCODING RNAS; LOW-FREQUENCY; CARCINOMA;

D O I：

10.1155/2016/6021934

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MicroRNAs are short (21-23 nucleotides), noncoding RNAs that typically silence posttranscriptional gene expression through interaction with target messenger RNAs. Currently, miRNAs have been identified in almost all studied multicellular eukaryotes in the plant and animal kingdoms. Additionally, recent studies reported that miRNAs can also be encoded by certain single-cell eukaryotes and by viruses. The vast majority of viral miRNAs are encoded by the herpesviruses family. These DNA viruses including Epstein-Barr virus encode their own miRNAs and/or manipulate the expression of cellular miRNAs to facilitate respective infection cycles. Modulation of the control pathways of miRNAs expression is often involved in the promotion of tumorigenesis through a specific cascade of transduction signals. Notably, latent infection with Epstein-Barr virus is considered liable of causing several types of malignancies, including the majority of gastric carcinoma cases detected worldwide. In this review, we describe the role of the Epstein-Barr virus in gastric carcinogenesis, summarizing the functions of the Epstein-Barr virus-encoded viral proteins and related epigenetic alterations as well as the roles of Epstein-Barr virus-encoded and virally modulated cellular miRNAs.

引用

页数：11

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