The gut microbiome and microbial translocation in multiple sclerosis

被引：52
作者：
Mirza, Ali [1 ,2 ]
Mao-Draayer, Yang [3 ]
机构：
[1] Univ Michigan, Sch Med, Dept Microbiol & Immunol, 4258 Alfred Taubman Biomed Sci Res Bldg, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Med, Dept Neurol, 4258 Alfred Taubman Biomed Sci Res Bldg, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Sch Med, Dept Neurol, 4015 Alfred Taubman Biomed Sci Res Bldg, Ann Arbor, MI 48109 USA
来源：
CLINICAL IMMUNOLOGY | 2017年 / 183卷
关键词：
Multiple sclerosis; Microbiome; CNS; Gut-brain axis; Microbial translocation; Intestinal permeability; CHAIN FATTY-ACIDS; BUTYRATE-PRODUCING BACTERIA; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; PATTERN-RECOGNITION RECEPTORS; INTESTINAL BARRIER FUNCTION; INFLAMMATORY-BOWEL-DISEASE; TOLL-LIKE RECEPTORS; REGULATORY T-CELLS; FAECALIBACTERIUM-PRAUSNITZII; FECAL MICROBIOTA;
D O I：
10.1016/j.clim.2017.03.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Individuals with multiple sclerosis (MS) have a distinct intestinal microbial community (microbiota) and increased low-grade translocation of bacteria from the intestines into the circulation. The observed change of intestinal bacteria in MS patients regulate immune functions involved in MS pathogenesis. These functions include: systemic and central nervous system (CNS) immunity (including peripheral regulatory T cell function), the blood-brain barrier (BBB) permeability and CNS-resident cell activity. This review discusses the MS intestinal microbiota implication on MS systemic- and CNS-immunopathology. We introduce the possible contributions of MS low-grade microbial translocation (LG-MT) to the development of MS, and end on a discussion on microbiota therapies for MS patients. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码：213 / 224
页数：12
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