The gut microbiome and microbial translocation in multiple sclerosis

被引：52
作者：
Mirza, Ali [1 ,2 ]
Mao-Draayer, Yang [3 ]
机构：
[1] Univ Michigan, Sch Med, Dept Microbiol & Immunol, 4258 Alfred Taubman Biomed Sci Res Bldg, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Med, Dept Neurol, 4258 Alfred Taubman Biomed Sci Res Bldg, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Sch Med, Dept Neurol, 4015 Alfred Taubman Biomed Sci Res Bldg, Ann Arbor, MI 48109 USA
来源：
CLINICAL IMMUNOLOGY | 2017年 / 183卷
关键词：
Multiple sclerosis; Microbiome; CNS; Gut-brain axis; Microbial translocation; Intestinal permeability; CHAIN FATTY-ACIDS; BUTYRATE-PRODUCING BACTERIA; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; PATTERN-RECOGNITION RECEPTORS; INTESTINAL BARRIER FUNCTION; INFLAMMATORY-BOWEL-DISEASE; TOLL-LIKE RECEPTORS; REGULATORY T-CELLS; FAECALIBACTERIUM-PRAUSNITZII; FECAL MICROBIOTA;
D O I：
10.1016/j.clim.2017.03.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Individuals with multiple sclerosis (MS) have a distinct intestinal microbial community (microbiota) and increased low-grade translocation of bacteria from the intestines into the circulation. The observed change of intestinal bacteria in MS patients regulate immune functions involved in MS pathogenesis. These functions include: systemic and central nervous system (CNS) immunity (including peripheral regulatory T cell function), the blood-brain barrier (BBB) permeability and CNS-resident cell activity. This review discusses the MS intestinal microbiota implication on MS systemic- and CNS-immunopathology. We introduce the possible contributions of MS low-grade microbial translocation (LG-MT) to the development of MS, and end on a discussion on microbiota therapies for MS patients. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码：213 / 224
页数：12
相关论文
共 50 条
[41]   Fractures and the gut microbiome [J].
McGinty, Tara ;
Mallon, Paddy W. G. .
CURRENT OPINION IN HIV AND AIDS, 2018, 13 (01) :28-37
[42]   The Role of the Gut Microbiome in Multiple Sclerosis Risk and Progression: Towards Characterization of the “MS Microbiome” [J].
Anne-Katrin Pröbstel ;
Sergio E. Baranzini .
Neurotherapeutics, 2018, 15 :126-134
[43]   The Role of the Gut Microbiome in Multiple Sclerosis Risk and Progression: Towards Characterization of the "MS Microbiome" [J].
Probstel, Anne-Katrin . ;
Baranzini, Sergio E. .
NEUROTHERAPEUTICS, 2018, 15 (01) :126-134
[44]   Diet, Microbiome and Multiple Sclerosis [J].
Haghikia, Aiden ;
Linker, Ralf .
AKTUELLE NEUROLOGIE, 2018, 45 (01) :24-28
[45]   The Role of the Intestinal Microbiome in Multiple Sclerosis-Lessons to Be Learned from Hippocrates [J].
El-Sayed, Mohamed Mahmoud ;
Mohak, Sidhesh ;
Gala, Dhir ;
Fabian, Reka ;
Peterfi, Zoltan ;
Fabian, Zsolt .
BIOLOGY-BASEL, 2023, 12 (12)
[46]   Gut-CNS-Axis as Possibility to Modulate Inflammatory Disease Activity-Implications for Multiple Sclerosis [J].
Fleck, Ann-Katrin ;
Schuppan, Detlef ;
Wiendl, Heinz ;
Klotz, Luisa .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (07)
[47]   Multiple sclerosis and the microbiota Progress in understanding the contribution of the gut microbiome to disease [J].
Engelenburg, Hendrik J. ;
Lucassen, Paul J. ;
Sarafian, Joshua T. ;
Parker, William ;
Laman, Jon D. .
EVOLUTION MEDICINE AND PUBLIC HEALTH, 2022, 10 (01) :277-294
[48]   The metabolic potential of the paediatric-onset multiple sclerosis gut microbiome [J].
Mirza, Ali, I ;
Zhu, Feng ;
Knox, Natalie ;
Forbes, Jessica D. ;
Bonner, Christine ;
Van Domselaar, Gary ;
Bernstein, Charles N. ;
Graham, Morag ;
Marrie, Ruth Ann ;
Hart, Janace ;
Yeh, E. Ann ;
Arnold, Douglas L. ;
Bar-Or, Amit ;
O'Mahony, Julia ;
Zhao, Yinshan ;
Hsiao, William ;
Banwell, Brenda ;
Waubant, Emmanuelle ;
Tremlett, Helen .
MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2022, 63
[49]   Implications of Diet and The Gut Microbiome in Neuroinflammatory and Neurodegenerative Diseases [J].
Hirschberg, Sarah ;
Gisevius, Barbara ;
Duscha, Alexander ;
Haghikia, Aiden .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (12)
[50]   The immunomodulatory roles of the gut microbiome in autoimmune diseases of the central nervous system: Multiple sclerosis as a model [J].
Hoffman, Kristina ;
Brownell, Zackariah ;
Doyle, William J. ;
Ochoa-Reparaz, Javier .
JOURNAL OF AUTOIMMUNITY, 2023, 137
12345