The gut microbiome and microbial translocation in multiple sclerosis

被引：52

作者：

Mirza, Ali ^{[1
,2
]}

Mao-Draayer, Yang ^{[3
]}

机构：

[1] Univ Michigan, Sch Med, Dept Microbiol & Immunol, 4258 Alfred Taubman Biomed Sci Res Bldg, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Dept Neurol, 4258 Alfred Taubman Biomed Sci Res Bldg, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Sch Med, Dept Neurol, 4015 Alfred Taubman Biomed Sci Res Bldg, Ann Arbor, MI 48109 USA

来源：

CLINICAL IMMUNOLOGY | 2017年 / 183卷

关键词：

Multiple sclerosis; Microbiome; CNS; Gut-brain axis; Microbial translocation; Intestinal permeability; CHAIN FATTY-ACIDS; BUTYRATE-PRODUCING BACTERIA; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; PATTERN-RECOGNITION RECEPTORS; INTESTINAL BARRIER FUNCTION; INFLAMMATORY-BOWEL-DISEASE; TOLL-LIKE RECEPTORS; REGULATORY T-CELLS; FAECALIBACTERIUM-PRAUSNITZII; FECAL MICROBIOTA;

D O I：

10.1016/j.clim.2017.03.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Individuals with multiple sclerosis (MS) have a distinct intestinal microbial community (microbiota) and increased low-grade translocation of bacteria from the intestines into the circulation. The observed change of intestinal bacteria in MS patients regulate immune functions involved in MS pathogenesis. These functions include: systemic and central nervous system (CNS) immunity (including peripheral regulatory T cell function), the blood-brain barrier (BBB) permeability and CNS-resident cell activity. This review discusses the MS intestinal microbiota implication on MS systemic- and CNS-immunopathology. We introduce the possible contributions of MS low-grade microbial translocation (LG-MT) to the development of MS, and end on a discussion on microbiota therapies for MS patients. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：213 / 224

页数：12

共 50 条

[21] Focus on the gut-brain axis: multiple sclerosis, the intestinal barrier and the microbiome [J].

Carlos R Camara-Lemarroy ;

Luanne M Metz ;

V Wee Yong .

World Journal of Gastroenterology, 2018, (37) :4-10

[22] The Emerging Role of the Gut Microbiome in Adult Patients With Multiple Sclerosis [J].

Newland, Pamela K. ;

Heitkemper, Margaret ;

Zhou, Yanjiao .

JOURNAL OF NEUROSCIENCE NURSING, 2016, 48 (06) :358-364

[23] Alterations of host-gut microbiome interactions in multiple sclerosis [J].

Cantoni, Claudia ;

Lin, Qingqi ;

Dorsett, Yair ;

Ghezzi, Laura ;

Liu, Zhongmao ;

Pan, Yeming ;

Chen, Kun ;

Han, Yanhui ;

Li, Zhengze ;

Xiao, Hang ;

Gormley, Matthew ;

Liu, Yue ;

Bokoliya, Suresh ;

Panier, Hunter ;

Suther, Cassandra ;

Evans, Emily ;

Deng, Li ;

Locca, Alberto ;

Mikesell, Robert ;

Obert, Kathleen ;

Newland, Pamela ;

Wu, Yufeng ;

Salter, Amber ;

Cross, Anne H. ;

Tarr, Phillip, I ;

Lovett-Racke, Amy ;

Piccio, Laura ;

Zhou, Yanjiao .

EBIOMEDICINE, 2022, 76

[24] The gut microbiome molecular mimicry piece in the multiple sclerosis puzzle [J].

Elsayed, Noha S. S. ;

Aston, Paula ;

Bayanagari, Vishnu R. R. ;

Shukla, Sanjay K. K. .

FRONTIERS IN IMMUNOLOGY, 2022, 13

[25] Alterations of the human gut microbiome in multiple sclerosis [J].

Jangi, Sushrut ;

Gandhi, Roopali ;

Cox, Laura M. ;

Li, Ning ;

von Glehn, Felipe ;

Yan, Raymond ;

Patel, Bonny ;

Mazzola, Maria Antonietta ;

Liu, Shirong ;

Glanz, Bonnie L. ;

Cook, Sandra ;

Tankou, Stephanie ;

Stuart, Fiona ;

Melo, Kirsy ;

Nejad, Parham ;

Smith, Kathleen ;

Topcuolu, Begum D. ;

Holden, James ;

Kivisakk, Pia ;

Chitnis, Tanuja ;

De Jager, Philip L. ;

Quintana, Francisco J. ;

Gerber, Georg K. ;

Bry, Lynn ;

Weiner, Howard L. .

NATURE COMMUNICATIONS, 2016, 7

[26] Emerging Concepts on the Gut Microbiome and Multiple Sclerosis [J].

Glenn, Justin D. ;

Mowry, Ellen M. .

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2016, 36 (06) :347-357

[27] Unraveling the Role of the Human Gut Microbiome in Health and Diseases [J].

Khalil, Mohamad ;

Di Ciaula, Agostino ;

Mahdi, Laura ;

Jaber, Nour ;

Di Palo, Domenica Maria ;

Graziani, Annarita ;

Baffy, Gyorgy ;

Portincasa, Piero .

MICROORGANISMS, 2024, 12 (11)

[28] Host Genetics and Gut Microbiome: Perspectives for Multiple Sclerosis [J].

Maglione, Alessandro ;

Zuccala, Miriam ;

Tosi, Martina ;

Clerico, Marinella ;

Rolla, Simona .

GENES, 2021, 12 (08)

[29] Multiple sclerosis, the microbiome, TLR2, and the hygiene hypothesis [J].

Wasko, Nicholas J. ;

Nichols, Frank ;

Clark, Robert B. .

AUTOIMMUNITY REVIEWS, 2020, 19 (01)

[30] The influence of aging and the microbiome in multiple sclerosis and other neurologic diseases [J].

Fettig, Naomi M. ;

Pu, Annie ;

Osborne, Lisa C. ;

Gommerman, Jennifer L. .

IMMUNOLOGICAL REVIEWS, 2024, 325 (01) :166-189

← 1 2 3 4 5 →