Electrochemistry and Determination of an Antiviral Drug at Ionic Liquids Crystals-Carbon Nanotubes Modified Glassy Carbon Electrode

被引：15
作者：
Galal, Ahmed [1 ]
Ahmed, Yousef M. [1 ]
Ahmed, Mansour H. M. [1 ]
Atta, Nada F. [1 ]
机构：
[1] Cairo Univ, Dept Chem, Fac Sci, Giza 12613, Egypt
来源：
JOURNAL OF THE ELECTROCHEMICAL SOCIETY | 2021年 / 168卷 / 11期
关键词：
Ionic Liquid Crystals; Favipiravir; Carbon Nanotubes; Electroanalytical Electrochemistry; Modified Electrode; SENSOR; FAVIPIRAVIR;
D O I：
10.1149/1945-7111/ac39d6
中图分类号：
O646 [电化学、电解、磁化学];
学科分类号：
081704 ;
摘要：
Favipiravir (Fav) is an antiviral drug administered for the treatment of pulmonary infection and is also among the approved drugs for the treatment of lung inflammation in humans infected with COVID-19. Here we introduce the electrochemical behavior of Fav at ionic liquid crystals (ILCs)-carbon nanotubes (CNTs) modified electrode. The proposed electrode is ready for use in a one-step preparation protocol, is employed with low-cost instrumentation, and is distinctly sensitive and selective for the determination of the drug both in human serum and in commercially available medications. Ionic liquid crystals allow ionic interaction with the drug to realize its surface preconcentration. The limits of detection and quantification for the determination of Fav in blood-serum within the concentration range 0.9 to 150 mu mol l(-1) are 0.0161 and 0.119 mu mol l(-1), respectively. The sensor proved effective in the concurrent determination of several drugs used as prescribed "add-on" medication for the virus or for the treatment of other chronic diseases of some patients.
引用
收藏
页数：11
相关论文
共 50 条
[21]   Voltammetric oxidation and determination of cinnarizine at glassy carbon electrode modified with multi-walled carbon nanotubes [J].
Hegde, Rajesh N. ;
Hosamani, Ragunatharaddi R. ;
Nandibewoor, Sharanappa T. .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2009, 72 (02) :259-265
[22]   AMPEROMETRIC DETERMINATION OF CHOLESTEROL-REDUCING DRUG, EZETIMIBE, USING GLASSY CARBON ELECTRODE MODIFIED WITH MULTIWALLED CARBON NANOTUBES AND SODIUM DODECYLSULFATE [J].
Jalali, F. ;
Ahmadi, E. ;
Roushani, M. ;
Bahrami, Gh. ;
Shamsipur, M. .
ANALYTICAL LETTERS, 2010, 43 (09) :1481-1490
[23]   Electro-oxidation and determination of antihistamine drug, cetirizine dihydrochloride at glassy carbon electrode modified with multi-walled carbon nanotubes [J].
Patil, Roopa H. ;
Hegde, Rajesh N. ;
Nandibewoor, Sharanappa T. .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2011, 83 (01) :133-138
[24]   Direct electrochemistry of Hemoglobin immobilized on carbon paste electrode modified by carbon nanotubes [J].
Li, YP ;
Cao, HB ;
Zhang, Y .
ACTA PHYSICO-CHIMICA SINICA, 2005, 21 (02) :187-191
[25]   Quantification of methyldopa in pharmaceuticals using a glassy carbon electrode modified with carbon nanotubes [J].
Kutluay, Aysegul ;
Aslanoglu, Mehmet .
CHINESE CHEMICAL LETTERS, 2016, 27 (01) :91-95
[26]   Electrocatalytic oxidation of NADH at an ordered carbon nanotubes modified glassy carbon electrode [J].
Chen, J ;
Bao, JC ;
Cai, CX ;
Lu, TH .
ANALYTICA CHIMICA ACTA, 2004, 516 (1-2) :29-34
[27]   Quantification of methyldopa in pharmaceuticals using a glassy carbon electrode modified with carbon nanotubes [J].
Aysegul Kutluay ;
Mehmet Aslanoglu .
ChineseChemicalLetters, 2016, 27 (01) :91-95
[28]   A glassy carbon electrode modified with β-cyclodextin, multiwalled carbon nanotubes and graphene oxide for sensitive determination of 1,3-dinitrobenzene [J].
Li, Junhua ;
Feng, Haibo ;
Feng, Yonglan ;
Liu, Jinlong ;
Liu, Youcai ;
Jiang, Jianbo ;
Qian, Dong .
MICROCHIMICA ACTA, 2014, 181 (11-12) :1369-1377
[29]   Glassy Carbon Electrode Modified with Functionalized Carbon Nanotubes Within a Poly(allylamine hydrochloride) Film for the Voltammetric Determination of Sulfite in Foods [J].
Sartori, Elen Romao ;
Takeda, Humberto Hissashi ;
Fatibello-Filho, Orlando .
ELECTROANALYSIS, 2011, 23 (11) :2526-2533
[30]   VOLTAMMETRIC DETERMINATION OF METHYLPARABAN IN COSMETICS USING A MULTI-WALL CARBON NANOTUBES/NAFION COMPOSITE MODIFIED GLASSY CARBON ELECTRODE [J].
Luo, Peili ;
Liu, Jie ;
Li, Yamin ;
Miao, Yurui ;
Ye, Baoxian .
ANALYTICAL LETTERS, 2012, 45 (16) :2445-2454
12345