Exploiting DNA repair defects for novel cancer therapies

被引：20
作者：
van Gent, Dik C. [1 ]
Kanaar, Roland [1 ,2 ]
机构：
[1] Erasmus Univ, Med Ctr, Canc Genom Netherlands, Dept Mol Genet, NL-3015 Rotterdam, Netherlands
[2] Erasmus Univ, Med Ctr, Dept Radiat Oncol, NL-3015 Rotterdam, Netherlands
来源：
MOLECULAR BIOLOGY OF THE CELL | 2016年 / 27卷 / 14期
关键词：
STRAND BREAK REPAIR; HOMOLOGOUS RECOMBINATION; POLY(ADP-RIBOSE) POLYMERASE; TARGETED THERAPY; INHIBITION; TUMORS; CELLS; MTH1; HYPERTHERMIA; PATHWAYS;
D O I：
10.1091/mbc.E15-10-0698
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Most human tumors accumulate a multitude of genetic changes due to defects in the DNA damage response. Recently, small-molecule inhibitors have been developed that target cells with specific DNA repair defects, providing hope for precision treatment of such tumors. Here we discuss the rationale behind these therapies and how an important bottleneck-patient selection-can be approached.
引用
收藏
页码：2145 / 2148
页数：4
相关论文
共 50 条
  • [41] Novel therapies for pancreatic cancer: setbacks and progress
    Wong, Han Hsi
    Lemoine, Nicholas R.
    FUTURE ONCOLOGY, 2010, 6 (07) : 1061 - 1064
  • [42] Nanotechnology in Cancer Therapy: Targeting the Inhibition of Key DNA Repair Pathways
    Aziz, K.
    Nowsheen, S.
    Georgakilas, A. G.
    CURRENT MOLECULAR MEDICINE, 2010, 10 (07) : 626 - 639
  • [43] DNA Damage Response and Mismatch Repair Gene Defects in Advanced and Metastatic Prostate Cancer
    Akhoundova, Dilara
    Francica, Paola
    Rottenberg, Sven
    Rubin, Mark A.
    ADVANCES IN ANATOMIC PATHOLOGY, 2024, 31 (02) : 61 - 69
  • [44] Novel roles of 1α,25(OH)2D3 on DNA repair provide new strategies for breast cancer treatment
    Gonzalo, Susana
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2014, 144 : 59 - 64
  • [45] A Curative DNA Code for Hematopoietic Defects Novel Cell Therapies for Monogenic Diseases of the Blood and Immune System
    Porteus, Matthew H.
    Pavel-Dinu, Mara
    Pai, Sung-Yun
    HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2022, 36 (04) : 647 - 665
  • [46] Loss of TGFβ signaling increases alternative end-joining DNA repair that sensitizes to genotoxic therapies across cancer types
    Liu, Qi
    Palomero, Luis
    Moore, Jade
    Guix, Ines
    Espin, Roderic
    Aytes, Alvaro
    Mao, Jian-Hua
    Paulovich, Amanda G.
    Whiteaker, Jeffrey R.
    Ivey, Richard G.
    Iliakis, George
    Luo, Daxian
    Chalmers, Anthony J.
    Murnane, John
    Pujana, Miquel Angel
    Barcellos-Hoff, Mary Helen
    SCIENCE TRANSLATIONAL MEDICINE, 2021, 13 (580)
  • [47] Exploiting DNA Damage Repair in Precision Cancer Therapy: BRCA1 as a Prime Therapeutic Target
    Raimundo, Liliana
    Calheiros, Juliana
    Saraiva, Lucilia
    CANCERS, 2021, 13 (14)
  • [48] Balancing DNA repair to prevent ageing and cancer
    Stead, Eleanor Rachel
    Bjedov, Ivana
    EXPERIMENTAL CELL RESEARCH, 2021, 405 (02)
  • [49] Epigenetic targeting of DNA repair in lung cancer
    Lok, Benjamin H.
    Rudin, Charles M.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (45) : 22429 - 22431
  • [50] DNA repair deficiency as a therapeutic target in cancer
    Martin, Sarah A.
    Lord, Christopher J.
    Ashworth, Alan
    CURRENT OPINION IN GENETICS & DEVELOPMENT, 2008, 18 (01) : 80 - 86
12345