Exploiting DNA repair defects for novel cancer therapies

被引：20

作者：

van Gent, Dik C. ^{[1
]}

Kanaar, Roland ^{[1
,2
]}

机构：

[1] Erasmus Univ, Med Ctr, Canc Genom Netherlands, Dept Mol Genet, NL-3015 Rotterdam, Netherlands

[2] Erasmus Univ, Med Ctr, Dept Radiat Oncol, NL-3015 Rotterdam, Netherlands

来源：

MOLECULAR BIOLOGY OF THE CELL | 2016年 / 27卷 / 14期

关键词：

STRAND BREAK REPAIR; HOMOLOGOUS RECOMBINATION; POLY(ADP-RIBOSE) POLYMERASE; TARGETED THERAPY; INHIBITION; TUMORS; CELLS; MTH1; HYPERTHERMIA; PATHWAYS;

D O I：

10.1091/mbc.E15-10-0698

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Most human tumors accumulate a multitude of genetic changes due to defects in the DNA damage response. Recently, small-molecule inhibitors have been developed that target cells with specific DNA repair defects, providing hope for precision treatment of such tumors. Here we discuss the rationale behind these therapies and how an important bottleneck-patient selection-can be approached.

引用

页码：2145 / 2148

页数：4

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