Platonin mitigates acute lung injury in haemorrhagic shock rats

被引:7
作者
Chu, Hsi-Ning [1 ,2 ]
Tsai, Pei-Shan [3 ]
Wang, Tao-Yeuan [4 ]
Huang, Chun-Jen [1 ,2 ]
机构
[1] Buddhist Tzu Chi Gen Hosp, Dept Anaesthesiol, Taipei Branch, Taipei, Taiwan
[2] Tzu Chi Univ, Sch Med, Hualien, Taiwan
[3] Taipei Med Univ, Coll Nursing, Taipei, Taiwan
[4] Mackay Mem Hosp, Dept Pathol, Taipei, Taiwan
关键词
Chemokine; Cytokine; Cyclooxygenase-2; Nitric oxide; Resuscitation; NF-KAPPA-B; NITRIC-OXIDE SYNTHASE; ELEMENT-BINDING PROTEIN; MURINE MACROPHAGES; OXIDATIVE STRESS; PHOTOSENSITIZING DYE; ACTIVATION; ENDOTOXEMIA; MECHANISMS; OXYGEN;
D O I
10.1016/j.resuscitation.2010.08.036
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Aim of the study: Enhanced oxidative stress and inflammatory response are crucial in mediating the development of acute lung injury induced by haemorrhagic shock with resuscitation. Platonin, a potent antioxidant, possesses potent anti-inflammation capacity. We sought to elucidate whether platonin could mitigate acute lung injury in haemorrhagic shock/resuscitation rats. Methods: Seventy-two adult male rats were randomized to receive haemorrhagic shock/resuscitation (HS), HS plus platonin (10, 50, or 100 mu g/kg intravenous injection immediately after resuscitation), sham instrumentation (Sham), or Sham plus platonin (100 mu g/kg) (n = 12 in each group). Haemorrhagic shock was induced by blood drawing and mean blood pressure was maintained at 40-45 mmHg for 120 min. Then, resuscitation was achieved by shed blood/saline mixtures re-infusion. After monitoring for another 8 h, rats were sacrificed. Results: Arterial blood gas and histological findings, in concert with assays of leukocyte infiltration (polymorphonuclear leukocytes/alveoli ratio and myeloperoxidase activity) and lung water content (wet/dry weight ratio), confirmed that haemorrhagic shock/resuscitation caused significant lung injury. Significant increases in concentrations of inflammatory molecules (chemokine, cytokine, and prostaglandin E-2) as well as nitric oxide and malondialdehyde in lung tissues confirmed that haemorrhagic shock/resuscitation elicited inflammatory response and imposed oxidative stress in rats. Platonin at the dosages of 50 and 100 mu g/kg, but not 10 mu g/kg, significantly attenuated the inflammatory response and oxidative stress induced by haemorrhagic shock/resuscitation. Most important, platonin at the dosages of 50 and 100 mu g/kg, but not 10 mu g/kg, significantly mitigated the lung injury induced by haemorrhagic shock/resuscitation. Conclusions: Platonin mitigates acute lung injury in haemorrhagic shock/resuscitation rats. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:97 / 104
页数:8
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