Nutritional and immunological factors in breast milk: A role in the intergenerational transmission from maternal psychopathology to child development

被引：33

作者：

Di Benedetto, Maria Grazia ^{[1
]}

Bottanelli, Chiara ^{[1
]}

Cattaneo, Annamaria ^{[1
,2
]}

Pariante, Carmine Maria ^{[1
,2
]}

Borsini, Alessandra ^{[1
]}

机构：

[1] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, Sect Stress Psychiat & Immunol & Perinatal Psychi, London, England

[2] IRCCS Ist Ctr San Giovanni Dio, Biol Psychiat Unit, Brescia, Italy

来源：

BRAIN BEHAVIOR AND IMMUNITY | 2020年 / 85卷

基金：

英国医学研究理事会;

关键词：

Breast milk composition; Perinatal depression; Perinatal anxiety; Child neurodevelopment; Child behavior; POLYUNSATURATED FATTY-ACIDS; PSYCHOSOCIAL STRESS; IMMUNOGLOBULIN-A; POSTPARTUM DEPRESSION; DOCOSAHEXAENOIC ACID; CYTOKINE PRODUCTION; ASSESSMENT SCALE; GUT MICROBIOTA; EARLY-LIFE; MOTHERS;

D O I：

10.1016/j.bbi.2019.05.032

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Perinatal psychopathologies affect more than 25% of women during and after their gestational period. These psychiatric disorders can potentially determine important biological variations in their organisms, affecting many different physiological and metabolic pathways. Of relevance, any of these changes occurring in the mother can alter the normal composition of breast milk, particularly the concentration of nutritional and inflammatory components, which play a role in child brain functioning and development. Indeed, there is evidence showing that changes in milk composition can contribute to cognitive impairments and alterations in mental abilities in children. This review aims to shed light on the unique intergenerational role played by breast milk composition, from maternal psychopathologies to child development.

引用

页码：57 / 68

页数：12

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