Effect of the chiral discrimination on the vibrational properties of (R)-, (S)- and (R, S)-ibuprofen/methyl-β-cyclodextrin inclusion complexes

被引：13

作者：

Crupi, V. ^{[1
,2
]}

Guella, G. ^{[3
]}

Majolino, D. ^{[1
,2
]}

Mancini, I. ^{[3
]}

Paciaroni, A. ^{[4
,5
]}

Rossi, B. ^{[3
,6
]}

Venuti, V. ^{[1
,2
]}

Verrocchio, P. ^{[3
]}

Viliani, G. ^{[3
]}

机构：

[1] Univ Messina, Dipartimento Fis, I-98166 Messina, Italy

[2] CNISM, I-98166 Messina, Italy

[3] Univ Trento, Dipartimento Fis, I-38123 Povo, Trento, Italy

[4] Univ Perugia, Dipartimento Fis, CEMIN, I-06123 Perugia, Italy

[5] INFM CRS SOFT, I-06123 Perugia, Italy

[6] Fdn Bruno Kessler, I-38123 Povo, Trento, Italy

来源：

PHILOSOPHICAL MAGAZINE | 2011年 / 91卷 / 13-15期

关键词：

ibuprofen; inclusion complex; FTIR-ATR spectroscopy; numerical simulation; chirality; CAPILLARY-ELECTROPHORESIS; IBUPROFEN; ENANTIOMERS; SEPARATION; NAPROXEN; ISOMERS; DRUGS;

D O I：

10.1080/14786435.2010.512575

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The effects of chiral discrimination of ibuprofen (IBP) on the complexation process with methyl-beta-cyclodextrin (Me-beta-CD) were investigated in the solid phase by FTIR-ATR spectroscopy and numerical simulation. The inclusion mechanism was deduced from the temperature-dependent analysis of the vibrational spectra, in the C=O stretching region, of complexes formed by Me-beta-CD with the two enantiomeric and the racemic forms of IBP. The mechanism turned out to be enthalpy-driven, with IBP enantiomers giving rise to more stable inclusion complexes with respect to the racemate.

引用

页码：1776 / 1785

页数：10

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