Severe cryptococcal-associated neurological immune reconstitution inflammatory syndrome in a renal transplant recipient treated with adalimumab

被引：4

作者：

Deshayes, S. ^{[1
]}

Bouvier, N. ^{[2
]}

Chatelet, V. ^{[2
]}

de Ligny, B. Hurault ^{[2
]}

Dargere, S. ^{[3
]}

Bonhomme, J. ^{[4
]}

Bechade, C. ^{[2
]}

机构：

[1] CHU Caen, Dept Internal Med, Caen, France

[2] CHU Caen, Dept Nephrol, F-14000 Caen, France

[3] CHU Caen, Dept Infect Dis, Caen, France

[4] CHU Caen, Dept Microbiol, Caen, France

来源：

TRANSPLANT INFECTIOUS DISEASE | 2016年 / 18卷 / 03期

关键词：

cryptococcosis; Cryptococcus neoformans; kidney transplantation; anti-tumor necrosis factor-alpha monoclonal antibody; immune reconstitution inflammatory syndrome; INVASIVE FUNGAL-INFECTIONS; ANTIRETROVIRAL THERAPY; NEOFORMANS INFECTION; DISEASE; TUBERCULOSIS; THALIDOMIDE;

D O I：

10.1111/tid.12522

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cryptococcosis is a major concern in organ transplant recipients. A decrease in immunosuppressants following the initiation of antifungal therapy is currently recommended, but can occasionally be complicated by the onset of immune reconstitution inflammatory syndrome (IRIS). We report on a case of cryptococcosis in a kidney transplant recipient, compounded by severe neurological IRIS, the outcome of which was unfavorable despite the use of anti-tumor necrosis factor-alpha monoclonal antibodies.

引用

页码：461 / 465

页数：5

共 32 条

[11]

Husain S, 2001, EMERG INFECT DIS, V7, P375

[12] Exacerbation of the inflammatory response to Mycobacterium tuberculosis after antiretroviral therapy [J].