Severe cryptococcal-associated neurological immune reconstitution inflammatory syndrome in a renal transplant recipient treated with adalimumab

被引：4

作者：

Deshayes, S. ^{[1
]}

Bouvier, N. ^{[2
]}

Chatelet, V. ^{[2
]}

de Ligny, B. Hurault ^{[2
]}

Dargere, S. ^{[3
]}

Bonhomme, J. ^{[4
]}

Bechade, C. ^{[2
]}

机构：

[1] CHU Caen, Dept Internal Med, Caen, France

[2] CHU Caen, Dept Nephrol, F-14000 Caen, France

[3] CHU Caen, Dept Infect Dis, Caen, France

[4] CHU Caen, Dept Microbiol, Caen, France

来源：

TRANSPLANT INFECTIOUS DISEASE | 2016年 / 18卷 / 03期

关键词：

cryptococcosis; Cryptococcus neoformans; kidney transplantation; anti-tumor necrosis factor-alpha monoclonal antibody; immune reconstitution inflammatory syndrome; INVASIVE FUNGAL-INFECTIONS; ANTIRETROVIRAL THERAPY; NEOFORMANS INFECTION; DISEASE; TUBERCULOSIS; THALIDOMIDE;

D O I：

10.1111/tid.12522

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cryptococcosis is a major concern in organ transplant recipients. A decrease in immunosuppressants following the initiation of antifungal therapy is currently recommended, but can occasionally be complicated by the onset of immune reconstitution inflammatory syndrome (IRIS). We report on a case of cryptococcosis in a kidney transplant recipient, compounded by severe neurological IRIS, the outcome of which was unfavorable despite the use of anti-tumor necrosis factor-alpha monoclonal antibodies.

引用

收藏

页码：461 / 465

页数：5

相关论文

共 32 条

[1] Cryptococcosis in Solid Organ Transplantation [J].

Baddley, J. W. ;

Forrest, G. N. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2013, 13 :242-249

[2]

Badiee P, 2011, EXP CLIN TRANSPLANT, V9, P355

[3] Population-Based Analysis of Invasive Fungal Infections, France, 2001-2010 [J].

Bitar, Dounia ;

Lortholary, Olivier ;

Le Strat, Yann ;

Nicolau, Javier ;

Coignard, Bruno ;

Tattevin, Pierre ;

Che, Didier ;

Dromer, Francoise .

EMERGING INFECTIOUS DISEASES, 2014, 20 (07) :1149-1155

[4] Therapeutic Use of Infliximab in Tuberculosis to Control Severe Paradoxical Reaction of the Brain and Lymph Nodes [J].

Blackmore, Timothy K. ;

Manning, Laurens ;

Taylor, William J. ;

Wallis, Robert S. .

CLINICAL INFECTIOUS DISEASES, 2008, 47 (10) :E83-E85

[5] Clinical Features and Serum Biomarkers in HIV Immune Reconstitution Inflammatory Syndrome after Cryptococcal Meningitis: A Prospective Cohort Study [J].

Boulware, David R. ;

Meya, David B. ;

Bergemann, Tracy L. ;

Wiesner, Darin L. ;

Rhein, Joshua ;

Musubire, Abdu ;

Lee, Sarah J. ;

Kambugu, Andrew ;

Janoff, Edward N. ;

Bohjanen, Paul R. .

PLOS MEDICINE, 2010, 7 (12)

[6] Comparison and Temporal Trends of Three Groups with Cryptococcosis: HIV-Infected, Solid Organ Transplant, and HIV-Negative/Non-Transplant [J].

Bratton, Emily W. ;

El Husseini, Nada ;

Chastain, Cody A. ;

Lee, Michael S. ;

Poole, Charles ;

Stuermer, Til ;

Juliano, Jonathan J. ;

Weber, David J. ;

Perfect, John R. .

PLOS ONE, 2012, 7 (08)

[7] Thalidomide for steroid-dependent immune reconstitution inflammatory syndromes during AIDS [J].

Brunel, Anne-Sophie ;

Reynes, Jacques ;

Tuaillon, Edouard ;

Rubbo, Pierre-Alain ;

Lortholary, Olivier ;

Montes, Brigitte ;

Le Moing, Vincent ;

Makinson, Alain .

AIDS, 2012, 26 (16) :2110-2112

[8]

Dromer F, 2015, RAPPORT ANN ACTIVITE

[9] Immune reconstitution syndrome and fungal infections [J].

Gupta, Ashish O. ;

Singh, Nina .

CURRENT OPINION IN INFECTIOUS DISEASES, 2011, 24 (06) :527-533

[10] Montelukast in the treatment of HIV associated immune reconstitution disease [J].

Hardwick, C. ;

White, D. ;

Morris, E. ;

Monteiro, E. F. ;

Breen, R. A. ;

Lipman, M. .

SEXUALLY TRANSMITTED INFECTIONS, 2006, 82 (06) :513-514

← 1 2 3 4 →