Comprehensive cross-sectional and longitudinal analyses of plasma neurofilament light across FTD spectrum disorders

被引：36

作者：

Gendron, Tania F. ^{[1
,2
]}

Heckman, Michael G. ^{[3
]}

White, Launia J. ^{[3
]}

Veire, Austin M. ^{[1
]}

Pedraza, Otto ^{[4
]}

Burch, Alexander R. ^{[5
]}

Bozoki, Andrea C. ^{[6
]}

Dickerson, Bradford C. ^{[7
]}

Domoto-Reilly, Kimiko ^{[8
]}

Foroud, Tatiana ^{[9
]}

Forsberg, Leah K. ^{[10
]}

Galasko, Douglas R. ^{[11
]}

Ghoshal, Nupur ^{[12
,13
]}

Graff-Radford, Neill R. ^{[5
]}

Grossman, Murray ^{[14
]}

Heuer, Hilary W. ^{[15
]}

Huey, Edward D. ^{[16
,17
]}

Hsiung, Ging-Yuek R. ^{[18
]}

Irwin, David J. ^{[19
]}

Kaufer, Daniel, I ^{[6
]}

Leger, Gabriel C. ^{[11
]}

Litvan, Irene ^{[11
]}

Masdeu, Joseph C. ^{[20
]}

Mendez, Mario F. ^{[21
,22
]}

Onyike, Chiadi U. ^{[23
]}

Pascual, Belen ^{[20
]}

Ritter, Aaron ^{[24
]}

Roberson, Erik D. ^{[25
]}

Rojas, Julio C. ^{[15
]}

Tartaglia, Maria Carmela ^{[26
]}

Wszolek, Zbigniew K. ^{[5
]}

Rosen, Howard ^{[15
]}

Boeve, Bradley F. ^{[10
]}

Boxer, Adam L. ^{[15
]}

Petrucelli, Leonard ^{[1
,2
]}

机构：

[1] Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

[2] Mayo Clin, Grad Sch Biomed Sci, Jacksonville, FL 32224 USA

[3] Mayo Clin, Div Clin Trials & Biostat, Jacksonville, FL 32224 USA

[4] Mayo Clin, Dept Psychiat & Psychol, Jacksonville, FL 32224 USA

[5] Mayo Clin, Dept Neurol, Jacksonville, FL 32224 USA

[6] Univ N Carolina, Dept Neurol, Chapel Hill, NC 27599 USA

[7] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

[8] Univ Washington, Dept Neurol, Seattle, WA 98104 USA

[9] Indiana Univ Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA

[10] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA

[11] Univ Calif San Diego, Parkinson & Other Movement Disorder Ctr, Dept Neurosci, La Jolla, CA 92037 USA

[12] Washington Univ, Dept Neurol, Sch Med, St Louis, MO 63110 USA

[13] Washington Univ, Dept Psychiat, Sch Med, St Louis, MO 63110 USA

[14] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

[15] Univ Calif San Francisco, Memory & Aging Ctr, Weill Inst Neurosci, Dept Neurol, San Francisco, CA 94158 USA

[16] Columbia Univ, Taub Inst, Dept Psychiat, New York, NY 10032 USA

[17] Columbia Univ, Taub Inst, Dept Neurol, New York, NY 10032 USA

[18] Univ British Columbia, Ctr Brain Hlth, Dept Med, Vancouver, BC V6T 1Z3, Canada

[19] Univ Penn, Dept Neurol, Perelman Sch Med, Philadelphia, PA 19104 USA

[20] Weill Cornell Med, Houston Methodist Res Inst, Stanley H Appel Dept Neurol, Nantz Natl Alzheimer Ctr, Houston, TX 77030 USA

[21] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90095 USA

[22] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA

[23] Johns Hopkins Univ, Dept Psychiat & Behav Sci, Baltimore, MD 21287 USA

[24] Cleveland Clin, Neurol Inst, Lou Ruvo Ctr Brain Hlth, Las Vegas, NV 89106 USA

[25] Univ Alabama Birmingham, Ctr Neurodegenerat & Expt Therapeut, Alzheimers Dis Ctr, Dept Neurol, Birmingham, AL 35294 USA

[26] Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Krembil Brain Inst, Dept Med,Div Neurol, Toronto, ON M5S 1A8, Canada

来源：

CELL REPORTS MEDICINE | 2022年 / 3卷 / 04期

关键词：

FRONTOTEMPORAL DEMENTIA; CEREBROSPINAL-FLUID; DISEASE PROGRESSION; CHAIN; DIAGNOSIS; BIOMARKER;

D O I：

10.1016/j.xcrm.2022.100607

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Frontotemporal dementia (FTD) therapy development is hamstrung by a lack of susceptibility, diagnostic, and prognostic biomarkers. Blood neurofilament light (NfL) shows promise as a biomarker, but studies have largely focused only on core FTD syndromes, often grouping patients with different diagnoses. To expedite the clinical translation of NfL, we avail ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) study resources and conduct a comprehensive investigation of plasma NfL across FTD syndromes and in presymptomatic FTD mutation carriers. We find plasma NfL is elevated in all studied syndromes, including mild cases; increases in presymptomatic mutation carriers prior to phenoconversion; and associates with indicators of disease severity. By facilitating the identification of individuals at risk of phenoconversion, and the early diagnosis of FTD, plasma NfL can aid in participant selection for prevention or early treatment trials. Moreover, its prognostic utility would improve patient care, clinical trial efficiency, and treatment outcome estimations.

引用

页数：19

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