Effect of Umbelliprenin on Antinociceptive Activity of Morphine in a Rat Model of Neuropathic Pain Induced by Chronic Constriction Injury of the Sciatic Nerve

被引：5
作者：
Nazemi, Samad [1 ]
Jafari, Faranak [2 ]
Amin, Bahareh [1 ]
Gholami, Omid [1 ]
Kafami, Marzieh [1 ]
Mojadadi, Mohammad-Shafi [3 ]
机构：
[1] Sabzevar Univ Med Sci, Cellular & Mol Res Ctr, Sch Med, Dept Physiol & Pharmacol, Sabzevar, Iran
[2] Sabzevar Univ Med Sci, Student Res Comm, Sabzevar, Iran
[3] Sabzevar Univ Med Sci, Leishmaniasis Res Ctr, Sabzevar 9613873136, Iran
来源：
NATURAL PRODUCTS JOURNAL | 2021年 / 11卷 / 03期
基金：
美国国家科学基金会;
关键词：
Neuropathic pain; Umbelliprenin; morphine; analgesia; hyperalgesia; allodynia; real-time polymerase chain reaction; tumor necrosis factor-alpha; PRENYLATED COUMARIN; REACTIVE OXYGEN; MOUSE MODEL; TNF-ALPHA; MINOCYCLINE; ACTIVATION; MECHANISMS; TOLERANCE;
D O I：
10.2174/2210315510999200421201705
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Objective: Although morphine is among the first-line medicines for the treatment of neuropathic pain, evidence has shown that the morphine efficacy gradually decreases and tolerance can occur. Regarding many reports concerning the antinociceptive and anti-inflammatory properties of umbelliprenin (UMB), this study aimed to investigate the effect of UMB on antinociceptive activity of morphine in a rat model of neuropathic pain induced by Chronic Constriction Injury (CCI) of the sciatic nerve. Methods: Twenty-four male Wistar rats were randomly divided into sham, CCI and CCI + UMB100 (100 mu g UMB per rat) groups. UMB was intrathecally administered once daily for four consecutive days (from the day before surgery until day 2 after surgery). All the animals received a single dose of morphine (5 mg/kg, s.c.) on day 14. To evaluate the effect of UMB on antinociceptive activity of morphine, allodynia and hyperalgesia were measured using the von-Frey and hot plate tests, before and 30 min after morphine injection and the Percentage of Maximum Possible Effect (%MPE) was calculated. Besides, the expression and concentration of tumor necrosis factor-alpha (TNF-alpha), as a proinflammatory cytokine, was measured in the spinal cord using quantitative real-time PCR (RTPCR) and ELISA, respectively. Results: UMB significantly enhanced anti-allodynic and anti-hyperalgesic effects of morphine in the neuropathic animals. Moreover, UMB considerably downregulated TNF-alpha expression in the spinal cord of the animals. Conclusion: UMB can enhance the antinociceptive effects of morphine, and this action may be partially due to its anti-inflammatory property.
引用
收藏
页码：392 / 399
页数：8
相关论文
共 35 条
[1]   A Systematic Review of NMDA Receptor Antagonists for Treatment of Neuropathic Pain in Clinical Practice [J].
Aiyer, Rohit ;
Mehta, Neel ;
Gungor, Semih ;
Gulati, Amitabh .
CLINICAL JOURNAL OF PAIN, 2018, 34 (05) :450-467
[2]  
Alizadeh MN, 2018, IRAN J PHARM RES, V17, P976
[3]   A simplified up-down method (SUDO) for measuring mechanical nociception in rodents using von Frey filaments [J].
Bonin, Robert P. ;
Bories, Cyril ;
De Koninck, Yves .
MOLECULAR PAIN, 2014, 10
[4]   Opioids for Chronic Noncancer Pain A Systematic Review and Meta-analysis [J].
Busse, Jason W. ;
Wang, Li ;
Kamaleldin, Mostafa ;
Craigie, Samantha ;
Riva, John J. ;
Montoya, Luis ;
Mulla, Sohail M. ;
Lopes, Luciane C. ;
Vogel, Nicole ;
Chen, Eric ;
Kirmayr, Karin ;
De Oliveira, Kyle ;
Olivieri, Lori ;
Kaushal, Alka ;
Chaparro, Luis E. ;
Oyberman, Inna ;
Agarwal, Arnav ;
Couban, Rachel ;
Tsoi, Ludwig ;
Lam, Tommy ;
Vandvik, Per Olav ;
Hsu, Sandy ;
Bala, Malgorzata M. ;
Schandelmaier, Stefan ;
Scheidecker, Anne ;
Ebrahim, Shanil ;
Ashoorion, Vahid ;
Rehman, Yasir ;
Hong, Patrick J. ;
Ross, Stephanie ;
Johnston, Bradley C. ;
Kunz, Regina ;
Sun, Xin ;
Buckley, Norman ;
Sessler, Daniel I. ;
Guyatt, Gordon H. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2018, 320 (23) :2448-2460
[5]   Inflammatory mediators of opioid tolerance: Implications for dependency and addiction [J].
Eidson, Lori N. ;
Murphy, Anne Z. .
PEPTIDES, 2019, 115 :51-58
[6]   Novel Endomorphin Analogs Are More Potent and Longer-Lasting Analgesics in Neuropathic, Inflammatory, Postoperative, and Visceral Pain Relative to Morphine [J].
Feehan, Amy K. ;
Morgenweck, Jenny ;
Zhang, Xing ;
Amgott-Kwan, Ariel T. ;
Zadina, James E. .
JOURNAL OF PAIN, 2017, 18 (12) :1526-1541
[7]   Characterization of the Degradation Profile of Umbelliprenin, a Bioactive Prenylated Coumarin of a Ferulago Species [J].
Genovese, Salvatore ;
Taddeo, Vito Alessandro ;
Epifano, Francesco ;
Fiorito, Serena ;
Bize, Cecile ;
Rives, Arnaud ;
de Medina, Philippe .
JOURNAL OF NATURAL PRODUCTS, 2017, 80 (09) :2424-2431
[8]  
Gholami O, 2013, IRAN J PHARM RES, V12, P371
[9]   Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1β, IL-6, and TNF-α in a mouse model of neuropathic pain [J].
Gopalsamy, Banulata ;
Farouk, Ahmad Akira Omar ;
Mohamad, Tengku Azam Shah Tengku ;
Sulaiman, Mohd Roslan ;
Perimal, Enoch Kumar .
JOURNAL OF PAIN RESEARCH, 2017, 10 :2605-2619
[10]   Nitroxidative Signaling Mechanisms in Pathological Pain [J].
Grace, Peter M. ;
Gaudet, Andrew D. ;
Staikopoulos, Vasiliki ;
Maier, Steven F. ;
Hutchinson, Mark R. ;
Salvemini, Daniela ;
Watkins, Linda R. .
TRENDS IN NEUROSCIENCES, 2016, 39 (12) :862-879
1234