Evolving Concepts in Lung Carcinogenesis

被引：57

作者：

Gomperts, Brigitte N. ^{[1
,2
]}

Spira, Avrum ^{[3
]}

Massion, Pierre P. ^{[4
,5
]}

Walser, Tonya C. ^{[1
]}

Wistuba, Ignacio I. ^{[6
]}

Minna, John D. ^{[7
]}

Dubinett, Steven M. ^{[1
,8
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Pulm & Crit Care Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Pediat, Div Hematol & Oncol, Mattel Childrens Hosp, Los Angeles, CA 90095 USA

[3] Boston Univ, Sch Med, Dept Med, Dept Pathol & Lab Med, Boston, MA 02118 USA

[4] Vanderbilt Ingram Canc Ctr, Dept Med, Dept Canc Biol, Thorac Oncol Ctr, Nashville, TN USA

[5] Vet Affairs Med Ctr, Div Pulm & Crit Care Med, Nashville, TN 37212 USA

[6] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USA

[7] Univ Texas SW Med Ctr Dallas, Dept Med, Dept Pharmacol, Dallas, TX 75390 USA

[8] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

来源：

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE | 2011年 / 32卷 / 01期

关键词：

Field of cancerization; inflammation; stem cells; genomics; epigenomics; proteomics; CANCER STEM-CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; ALDEHYDE DEHYDROGENASE 1; DNA COPY-NUMBER; ABERRANT PROMOTER METHYLATION; GENE-EXPRESSION; BASAL-CELLS; CYCLOOXYGENASE-2-DEPENDENT REGULATION; RESPIRATORY EPITHELIUM; SUSCEPTIBILITY LOCUS;

D O I：

10.1055/s-0031-1272867

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Lung carcinogenesis is a complex, stepwise process that involves the acquisition of genetic mutations and epigenetic changes that alter cellular processes, such as proliferation, differentiation, invasion, and metastasis. Here, we review some of the latest concepts in the pathogenesis of lung cancer and highlight the roles of inflammation, the "field of cancerization," and lung cancer stem cells in the initiation of the disease. Furthermore, we review how high throughput genomics, transcriptomics, epigenomics, and proteomics are advancing the study of lung carcinogenesis. Finally, we reflect on the potential of current in vitro and in vivo models of lung carcinogenesis to advance the field and on the areas of investigation where major breakthroughs will lead to the identification of novel chemoprevention strategies and therapies for lung cancer.

引用

页码：32 / 43

页数：12

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