CoQ10 exerts hepatoprotective effect in fructose-induced fatty liver model in rats

被引:6
作者
Elshazly, Shimaa M. [1 ]
Alsemeh, Amira E. [2 ]
Ahmad, Enssaf A. A. [2 ]
Rezq, Samar [1 ,3 ]
机构
[1] Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig, Egypt
[2] Zagazig Univ, Fac Med, Dept Anat & Embryol, Zagazig, Egypt
[3] UMMC, Dept Cell & Mol Biol, 2500 N State St, Jackson, MS 39216 USA
关键词
Lipid profile; Adiponectin; Tyrosine kinase; PI3K; INSULIN-RESISTANCE; COENZYME Q(10); METABOLIC SYNDROME; OXIDATIVE STRESS; MESSENGER-RNA; APOPTOSIS; DISEASE; GLUCOSE; PROTEIN; INFLAMMATION;
D O I
10.1007/s43440-020-00075-5
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Background Excess dietary sugar is associated with deleterious metabolic effects, liver injury, and coenzyme-Q10 (CoQ10) deficiency. This study investigates the ability of CoQ10 to protect against fructose-induced hepatic damage. Methods Rats were fed tap water or 30% fructose for 12 weeks with or without CoQ10 (10 mg/kg, po). An additional group of rats were allowed to feed on either water or 30% fructose for 12 weeks, followed by four weeks of treatment with either the vehicle or CoQ10. Results Fructose-fed rats showed lower CoQ10 levels, increased systolic pressure, increased body weight, higher liquid consumption, decreased food intake and hyperglycemia. Fructose-fed rats also showed deteriorated serum and liver lipid profiles, impaired liver function tests and oxidative status, and lower expression of adiponectin receptor 1 and 2 along with higher GLUT-2 levels. Furthermore, following fructose treatment, tyrosine kinase-PI3K pathway was inhibited. Additionally, there was an increase in the levels of apoptotic markers and serum visfatin and a decrease in the levels of adiponectin and soluble receptor of the advanced glycated end product. Consequently, several histopathological changes were detected in the liver. Concurrent or three months post-exposure administration of CoQ10 in fructose rats significantly reversed or attenuated all the measured parameters and hepato-cytoarchitecture alterations. Conclusion This study suggests CoQ10 supplement as a possible prophylaxis or treatment candidate for fructose-induced liver injury. Graphic abstract
引用
收藏
页码:922 / 934
页数:13
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