Vascular Endothelial Growth Factor A Isoform mRNA Expression in Pediatric Acute Myeloid Leukemia

被引：8
|
作者：
Kruizinga, R. C. [1 ,2 ]
de Jonge, H. J. M. [1 ]
Kampen, K. R. [1 ]
Walenkamp, A. M. E. [2 ]
de Bont, E. S. J. M. [1 ]
机构：
[1] Univ Groningen, Div Pediat Oncol Hematol, Dept Pediat,Univ Med Ctr Groningen, Beatrix Childrens Hosp, NL-9700 RB Groningen, Netherlands
[2] Univ Groningen, Dept Med Oncol, Univ Med Ctr Groningen, NL-9700 RB Groningen, Netherlands
来源：
PEDIATRIC BLOOD & CANCER | 2011年 / 56卷 / 02期
关键词：
AML; isoform; VEGFA; SPLICE VARIANTS; VEGF-A; AML; 10; SURVIVAL; ANGIOGENESIS; TUMORS;
D O I：
10.1002/pbc.22783
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In AML high VEGFA protein expression correlates with poor overall and relapse-free survival (OS/RFS). To date, the relevance of the various VEGFA isoforms is unclear. We determined VEGF121, VEGF145, VEGF148, VEGF165, VEGF183, and VEGF189 mRNA expression in pediatric AML samples and investigated the relation between VEGFA isoform expression and clinicopatholologic characteristics and outcome. A significant co-expression of VEGF121, VEGF165, VEGF183, and VEGF189 isoforms was apparent (mean rho = 0.716, P<0.0001). This co-expression justifies measuring a single VEGFA isoform (e.g., 121, 165, 183, and 189) as representative expression of all VEGFA isoforms in future studies designed to determine the prognostic importance of VEGFA isoforms. Pediatr Blood Cancer 2011;56:294-297. (C) 2010 Wiley-Liss, Inc.
引用
收藏
页码：294 / 297
页数：4
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