A general synthetic approach to the amnesic shellfish toxins: total synthesis of (-)-isodomoic acid B, (-)-isodomoic acid E and (-)-isodomoic acid F

被引：30

作者：

Lemiere, Gilles ^{[1
]}

Sedehizadeh, Simon ^{[1
]}

Toueg, Julie ^{[1
]}

Fleary-Roberts, Nadia ^{[1
]}

Clayden, Jonathan ^{[1
]}

机构：

[1] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 13期

基金：

英国工程与自然科学研究理事会;

关键词：

VIVO SEIZURE INDUCTION; CHIRAL LITHIUM AMIDES; DOMOIC ACID; DEAROMATISING CYCLIZATION; ISODOMOIC ACIDS; STEREOSELECTIVE-SYNTHESIS; ASYMMETRIC-SYNTHESIS; RED ALGA; ISOMERS; IDENTIFICATION;

D O I：

10.1039/c1cc00048a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The alkynylpyrrolidine 4 was made via a dearomatising cyclisation of an aromatic amide, and was elaborated by stannylcupration and palladium-catalysed coupling to achieve the first total synthesis of three members of the isodomoic acid family; the same alkyne can be envisaged as a precursor to several more of this class of amnesic shellfish toxins.

引用

页码：3745 / 3747

页数：3

共 29 条

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