Relaxant Action of Plumula Nelumbinis Extract on Mouse Airway Smooth Muscle

被引：12

作者：

Tan, Li ^{[1
,2
]}

Chen, Weiwei ^{[1
,2
]}

Wei, Ming-Yu ^{[1
,2
]}

Shen, Jinhua ^{[1
,2
]}

Yu, Meng-Fei ^{[1
,2
]}

Yang, Guangzhong ^{[3
]}

Guo, Donglin ^{[4
,5
]}

Qin, Gangjian ^{[6
]}

Ji, Guangju ^{[7
]}

Liu, Qing-Hua ^{[1
,2
]}

机构：

[1] South Cent Univ Nationalities, Inst Med Biol, Coll Life Sci, Wuhan 430074, Peoples R China

[2] South Cent Univ Nationalities, Hubei Prov Key Lab Protect & Applicat Special Pla, Coll Life Sci, Wuhan 430074, Peoples R China

[3] South Cent Univ Nationalities, Coll Pharm, Wuhan 430074, Peoples R China

[4] Lankenau Inst Med Res, Wynnewood, PA 19096 USA

[5] Main Line Hlth Heart Ctr, Wynnewood, PA 19096 USA

[6] Northwestern Univ, Feinberg Sch Med, Dept Med Cardiol, Feinberg Cardiovasc Res Inst, Chicago, IL 60611 USA

[7] Chinese Acad Sci, Natl Lab Biomacromol, Inst Biophys, Beijing 100101, Peoples R China

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2015年 / 2015卷

基金：

中国国家自然科学基金;

关键词：

CA2+ RELEASE; CALCIUM; CELLS; ACTIVATION; ASTHMA; PROLIFERATION; CONTRACTILITY; CHANNELS; NEFERINE; STORE;

D O I：

10.1155/2015/523640

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

The traditional herb Plumula Nelumbinis is widely used in the world because it has many biological activities, such as anti-inflammation, antioxidant, antihypertension, and butyrylcholinesterase inhibition. However, the action of Plumula Nelumbinis on airway smooth muscle (ASM) relaxation has not been investigated. A chloroform extract of Plumula Nelumbinis (CEPN) was prepared, which completely inhibited precontraction induced by high K+ in a concentration-dependent manner in mouse tracheal rings, but it had no effect on resting tension. CEPN also blocked voltage-dependent L-type Ca2+ channel-(VDCC-) mediated currents. In addition, ACh-induced precontraction was also completely blocked by CEPN and partially inhibited by nifedipine or pyrazole 3. Besides, CEPN partially reduced ACh-activated nonselective cation channel (NSCC) currents. Taken together, our data demonstrate that CEPN blocked VDCC and NSCC to inhibit Ca2+ influx, resulting in relaxation of precontracted ASM. This finding indicates that CEPN would be a candidate of new potent bronchodilators.

引用

页数：10

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