Strain-specific spleen remodelling in Plasmodium yoelii infections in Balb/c mice facilitates adherence and spleen macrophage-clearance escape

被引：39

作者：

Martin-Jaular, Lorena ^{[1
]}

Ferrer, Mireia ^{[1
]}

Calvo, Maria ^{[2
]}

Rosanas-Urgell, Anna ^{[1
]}

Kalko, Susana ^{[3
]}

Graewe, Stefanie ^{[4
]}

Soria, Guadalupe ^{[5
,6
]}

Cortadellas, Nuria ^{[7
]}

Ordi, Jaume ^{[8
]}

Planas, Anna ^{[5
,6
]}

Burns, James ^{[9
]}

Heussler, Volker ^{[4
]}

del Portillo, Hernando A. ^{[1
,10
]}

机构：

[1] Barcelona Ctr Int Hlth Res, Barcelona, Spain

[2] Univ Barcelona IDIBAPS, Fac Med, Unitat Microscopia Confocal, Barcelona, Spain

[3] Hosp Clin Barcelona, IDIBAPS, Bioinformat Unit, Barcelona, Spain

[4] Bernhard Nocht Inst Trop Med, Dept Mol Parasitol, Malaria Lab, Hamburg, Germany

[5] CSIC, Dept Brain Ischemia & Neurodegenerat, IIBB, Inst Invest Biomed August Pi I Sunyer IDIBAPS, Barcelona, Spain

[6] IDIBAPS, Unitat Ressonancia Magnet Expt, Barcelona, Spain

[7] Univ Barcelona IDIBAPS, Fac Med, Unitat Microscopia Elect, Barcelona, Spain

[8] Hosp Clin Barcelona, Dept Anat Pathol, Barcelona, Spain

[9] Drexell Univ Med Coll, Dept Microbiol & Immunol, Philadelphia, PA USA

[10] ICREA, Barcelona, Spain

来源：

CELLULAR MICROBIOLOGY | 2011年 / 13卷 / 01期

关键词：

RODENT MALARIA PARASITE; MURINE MALARIA; LYMPH-NODE; ERYTHROCYTES; BLOOD; MICROSCOPY; BERGHEI; TRAFFICKING; RETENTION; CHABAUDI;

D O I：

10.1111/j.1462-5822.2010.01523.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

P>Knowledge of the dynamic features of the processes driven by malaria parasites in the spleen is lacking. To gain insight into the function and structure of the spleen in malaria, we have implemented intravital microscopy and magnetic resonance imaging of the mouse spleen in experimental infections with non-lethal (17X) and lethal (17XL) Plasmodium yoelii strains. Noticeably, there was higher parasite accumulation, reduced motility, loss of directionality, increased residence time and altered magnetic resonance only in the spleens of mice infected with 17X. Moreover, these differences were associated with the formation of a strain-specific induced spleen tissue barrier of fibroblastic origin, with red pulp macrophage-clearance evasion and with adherence of infected red blood cells to this barrier. Our data suggest that in this reticulocyte-prone non-lethal rodent malaria model, passage through the spleen is different from what is known in other Plasmodium species and open new avenues for functional/structural studies of this lymphoid organ in malaria.

引用

页码：109 / 122

页数：14

共 36 条

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