Statins enhance circulating vitamin E

被引:11
作者
Cangemi, Roberto [1 ]
Loffredo, Lorenzo [1 ]
Carnevale, Roberto [1 ]
Pignatelli, Pasquale [1 ]
Violi, Francesco [1 ]
机构
[1] Univ Roma La Sapienza, Dept Expt Med & Pathol, Div Clin Med 4, I-00161 Rome, Italy
关键词
oxidative stress; vitamin E; statin; metabolic syndrome;
D O I
10.1016/j.ijcard.2006.11.115
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Statins have been shown to inhibit oxidative stress, however it is still unclear if they influence antioxidant status. We performed a retrospective analysis of oxidative stress, as assessed by serum levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and vitamin E, a known antioxidant, in patients with metabolic syndrome (n = 112) treated (n = 30) or not (n = 82) with statins. Statin-treated patients showed higher levels of vitamin E (p = 0.02) and lower 8-OHdG (p<0.01) than statin-free patients. An inverse correlation between oxidative stress and vitamin E was observed (r = -0.670, p<0.001). These preliminary data suggest that statins enhance the antioxidant status likely by inhibiting oxidative stress. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:172 / 174
页数:3
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