A novel screening model for the molecular drug for diabetes and obesity based on tyrosine phosphatase Shp2

被引:19
作者
Bu, Yanyan [2 ,3 ]
Shi, Tao [1 ]
Meng, Minghui [2 ,3 ]
Kong, Guiping [2 ,3 ]
Tian, Yingpu [2 ,3 ]
Chen, Quancheng [1 ]
Yao, Xinsheng [1 ,4 ]
Feng, Gensheng [2 ,3 ,5 ]
Cheng, Haifeng [1 ]
Lu, Zhongxian [2 ,3 ]
机构
[1] Xiamen Univ, Nat Prod Res Ctr, Inst Biomed Res, Xiamen 361005, Fujian, Peoples R China
[2] Xiamen Univ, Xiamen City Key Lab Metab Dis, Xiamen 361005, Fujian, Peoples R China
[3] Xiamen Univ, Metab Dis Res Ctr, Inst Biomed Res, Xiamen 361005, Fujian, Peoples R China
[4] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China
[5] Univ Calif San Diego, Mol Pathol Grad Program, La Jolla, CA 92093 USA
基金
中国国家自然科学基金;
关键词
Shp2; enhancer; Screening system; Diabetes; Oleanolic acid; OLEANOLIC ACID; MEDICINAL FOODSTUFFS; INSULIN-SECRETION; RATS; EXPRESSION; RESISTANCE; INHIBITORS; DELETION; DEATH; MICE;
D O I
10.1016/j.bmcl.2010.11.049
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Tyrosine phosphatase Src-homology phosphotyrosyl phosphatase 2 (Shp2) was identified as a potential molecular target for therapeutic treatment of diabetes and obesity. However, there is still no systematic research on the enhancers for the Shp2 enzyme. The present study established a novel powerful model for the high-throughput screening of Shp2 enhancers and successfully identified a new specific Shp2 enhancer, oleanolic acid, from Chinese herbs. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码:874 / 878
页数:5
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