A novel screening model for the molecular drug for diabetes and obesity based on tyrosine phosphatase Shp2

被引：19

作者：

Bu, Yanyan ^{[2
,3
]}

Shi, Tao ^{[1
]}

Meng, Minghui ^{[2
,3
]}

Kong, Guiping ^{[2
,3
]}

Tian, Yingpu ^{[2
,3
]}

Chen, Quancheng ^{[1
]}

Yao, Xinsheng ^{[1
,4
]}

Feng, Gensheng ^{[2
,3
,5
]}

Cheng, Haifeng ^{[1
]}

Lu, Zhongxian ^{[2
,3
]}

机构：

[1] Xiamen Univ, Nat Prod Res Ctr, Inst Biomed Res, Xiamen 361005, Fujian, Peoples R China

[2] Xiamen Univ, Xiamen City Key Lab Metab Dis, Xiamen 361005, Fujian, Peoples R China

[3] Xiamen Univ, Metab Dis Res Ctr, Inst Biomed Res, Xiamen 361005, Fujian, Peoples R China

[4] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China

[5] Univ Calif San Diego, Mol Pathol Grad Program, La Jolla, CA 92093 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Shp2; enhancer; Screening system; Diabetes; Oleanolic acid; OLEANOLIC ACID; MEDICINAL FOODSTUFFS; INSULIN-SECRETION; RATS; EXPRESSION; RESISTANCE; INHIBITORS; DELETION; DEATH; MICE;

D O I：

10.1016/j.bmcl.2010.11.049

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Tyrosine phosphatase Src-homology phosphotyrosyl phosphatase 2 (Shp2) was identified as a potential molecular target for therapeutic treatment of diabetes and obesity. However, there is still no systematic research on the enhancers for the Shp2 enzyme. The present study established a novel powerful model for the high-throughput screening of Shp2 enhancers and successfully identified a new specific Shp2 enhancer, oleanolic acid, from Chinese herbs. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：874 / 878

页数：5

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