Mechanisms of Altered Regulation of Food Intake in Chronic Kidney Disease

被引:46
作者
Carrero, Juan J. [1 ,2 ,3 ,4 ]
机构
[1] Karolinska Inst, Div Renal Med, Stockholm, Sweden
[2] Karolinska Inst, Div Baxter Novum CLINTEC, Stockholm, Sweden
[3] Karolinska Inst, Ctr Mol Med, Stockholm, Sweden
[4] Karolinska Inst, Ctr Gender Med, Stockholm, Sweden
关键词
STAGE RENAL-DISEASE; PERITONEAL-DIALYSIS PATIENTS; GLUCOSE-BASED DIALYSATE; HEMODIALYSIS-PATIENTS; NUTRITIONAL-STATUS; NUTRIENT INTAKE; PLASMA GHRELIN; APPETITE; INFLAMMATION; LEPTIN;
D O I
10.1053/j.jrn.2010.10.004
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Patients with chronic kidney disease (CKD) frequently experience loss of appetite (anorexia), which increases in severity during disease progression. The optimal management of patients with CKD and overt anorexia depends on an appropriate understanding of the causes of anorexia that are related to advanced CKD. This review aims to provide an overview of the multifactorial mechanisms concurrently contributing to the high prevalence of anorexia in the uremic population with advanced CKD. (C) 2011 by the National Kidney Foundation, Inc. All rights reserved.
引用
收藏
页码:7 / 11
页数:5
相关论文
共 51 条
[1]   Gastrointestinal and pancreatic function in peritoneal dialysis patients:: Their relationship with malnutrition and peritoneal membrane abnormalities [J].
Aguilera, A ;
Bajo, MA ;
Espinoza, M ;
Olveira, A ;
Paiva, AM ;
Codoceo, R ;
García, P ;
Sánchez, S ;
Celadilla, O ;
Castro, MJ ;
Selgas, R .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2003, 42 (04) :787-796
[2]  
Anderstam B, 1996, J AM SOC NEPHROL, V7, P2453
[3]   Mouse tumor necrosis factor-α increases brain tryptophan concentrations and norepinephrine metabolism while activating the HPA axis in mice [J].
Ando, T ;
Dunn, AJ .
NEUROIMMUNOMODULATION, 1999, 6 (05) :319-329
[4]   Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin [J].
Asakawa, A ;
Inui, A ;
Fujimiya, M ;
Sakamaki, R ;
Shinfuku, N ;
Ueta, Y ;
Meguid, MM ;
Kasuga, M .
GUT, 2005, 54 (01) :18-24
[5]   Sustained appetite improvement in malnourished dialysis patients by daily ghrelin treatment [J].
Ashby, Damien R. ;
Ford, Heather E. ;
Wynne, Katie J. ;
Wren, Alison M. ;
Murphy, Kevin G. ;
Busbridge, Mark ;
Brown, Edwina A. ;
Taube, David H. ;
Ghatei, Mohammad A. ;
Tam, Frederick W. K. ;
Bloom, Stephen R. ;
Choi, Peter .
KIDNEY INTERNATIONAL, 2009, 76 (02) :199-206
[6]   Associations between plasma ghrelin levels and body composition in end-stage renal disease:: a longitudinal study [J].
Ayala, ER ;
Pecoits, R ;
Heimbürger, O ;
Lindholm, B ;
Nordfors, L ;
Stenvinkel, P .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2004, 19 (02) :421-426
[7]   Anorexia and serum leptin levels in hemodialysis patients [J].
Bossola, M ;
Muscaritoli, M ;
Valenza, V ;
Panocchia, N ;
Tazza, L ;
Cascino, A ;
Laviano, A ;
Liberatori, M ;
Moussier, ML ;
Fanelli, FR ;
Luciani, G .
NEPHRON CLINICAL PRACTICE, 2004, 97 (03) :76-82
[8]   Mechanisms and Treatment of Anorexia in End-Stage Renal Disease Patients on Hemodialysis [J].
Bossola, Maurizio ;
Tazza, Luigi ;
Luciani, Giovanna .
JOURNAL OF RENAL NUTRITION, 2009, 19 (01) :2-9
[9]   Anorexia and Plasma Levels of Free Tryptophan, Branched Chain Amino Acids, and Ghrelin in Hemodialysis Patients [J].
Bossola, Maurizio ;
Scribano, Donata ;
Colacicco, Luigi ;
Tavazzi, Barbara ;
Giungi, Stefania ;
Zuppi, Cecilia ;
Luciani, Giovanna ;
Tazza, Luigi .
JOURNAL OF RENAL NUTRITION, 2009, 19 (03) :248-255
[10]   Effects of dietary intake, appetite, and eating habits on dialysis and non-dialysis treatment days in hemodialysis patients: Cross-sectional results from the HEMO study [J].
Burrowes, JD ;
Larive, B ;
Cockram, DB ;
Dwyer, J ;
Kusek, JW ;
McLeroy, S ;
Poole, D ;
Rocco, MV .
JOURNAL OF RENAL NUTRITION, 2003, 13 (03) :191-198