Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

被引：269

作者：

D'Amico, Davide ^{[1
]}

Andreux, Penelope A. ^{[1
]}

Valdes, Pamela ^{[1
]}

Singh, Anurag ^{[1
]}

Rinsch, Chris ^{[1
]}

Auwerx, Johan ^{[2
]}

机构：

[1] Amazentis SA, EPFL Innovat Pk,Batiment C, CH-1015 Lausanne, Switzerland

[2] Ecole Polytech Fed Lausanne, Lab Integrat Syst Physiol, CH-1015 Lausanne, Switzerland

来源：

TRENDS IN MOLECULAR MEDICINE | 2021年 / 27卷 / 07期

关键词：

INTERVERTEBRAL DISC DEGENERATION; CISPLATIN-INDUCED NEPHROTOXICITY; ELLAGIC ACID; MEDITERRANEAN DIET; MITOCHONDRIAL; MITOPHAGY; ELLAGITANNINS; INTERVENTION; METABOLISM; AGE;

D O I：

10.1016/j.molmed.2021.04.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate, berries, and nuts. UA was discovered 40 years ago, but only recently has its impact on aging and disease been explored. UA enhances cellular health by increasing mitophagy and mitochondrial function and reducing detrimental inflammation. Several preclinical studies show how UA protects against aging and age-related conditions affecting muscle, brain, joints, and other organs. In humans, benefits of UA supplementation in the muscle are supported by recent clinical trials in elderly people. Here, we review the state of the art of UA's biology and its translational potential as a nutritional intervention in humans.

引用

页码：687 / 699

页数：13

共 69 条

[21] Inflammaging: a new immune-metabolic viewpoint for age-related diseases [J].

Franceschi, Claudio ;

Garagnani, Paolo ;

Parini, Paolo ;

Giuliani, Cristina ;

Santoro, Aurelia .

NATURE REVIEWS ENDOCRINOLOGY, 2018, 14 (10) :576-590

[22] The Microbiome-Mitochondrion Connection: Common Ancestries, Common Mechanisms, Common Goals [J].

Franco-Obregon, Alfredo ;

Gilbert, Jack A. .

MSYSTEMS, 2017, 2 (03)

[23] Urolithin A targets the PI3K/Akt/NF-κB pathways and prevents IL-1β-induced inflammatory response in human osteoarthritis: in vitro and in vivo studies [J].

Fu, Xin ;

Gong, Lan-Fang ;

Wu, Yi-Fan ;

Lin, Zeng ;

Jiang, Bing-Jie ;

Wu, Long ;

Yu, Ke-He .

FOOD & FUNCTION, 2019, 10 (09) :6135-6146

[24] Urolithin A augments angiogenic pathways in skeletal muscle by bolstering NAD+ and SIRT1 [J].

Ghosh, Nandini ;

Das, Amitava ;

Biswas, Nirupam ;

Gnyawali, Surya ;

Singh, Kanhaiya ;

Gorain, Mahadeo ;

Polcyn, Carly ;

Khanna, Savita ;

Roy, Sashwati ;

Sen, Chandan K. .

SCIENTIFIC REPORTS, 2020, 10 (01)

[25] Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice [J].

Gong, Zhuo ;

Huang, Jingyi ;

Xu, Biao ;

Ou, Zhenri ;

Zhang, Le ;

Lin, Xiaohong ;

Ye, Xiujuan ;

Kong, Xuejian ;

Long, Dahong ;

Sun, Xiangdong ;

He, Xiaosong ;

Xu, Liping ;

Li, Qingqing ;

Xuan, Aiguo .

JOURNAL OF NEUROINFLAMMATION, 2019, 16 (1)

[26] Bioavailability of Anthocyanins and Ellagitannins Following Consumption of Raspberries by Healthy Humans and Subjects with an Ileostomy [J].

Gonzalez-Barrio, Rocio ;

Borges, Gina ;

Mullen, William ;

Crozier, Alan .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2010, 58 (07) :3933-3939

[27] Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight-obese individuals consuming pomegranate: A randomized clinical trial [J].

Gonzalez-Sarrias, Antonio ;

Garcia-Villalba, Rocio ;

Romo-Vaquero, Maria ;

Alasalvar, Cesarettin ;

Orem, Asimo ;

Zafrilla, Pilar ;

Tomas-Barberan, Francisco A. ;

Selma, Maria V. ;

Carlos Espin, Juan .

MOLECULAR NUTRITION & FOOD RESEARCH, 2017, 61 (05)

[28] Urolithin A Mitigates Cisplatin-Induced Nephrotoxicity by Inhibiting Renal Inflammation and Apoptosis in an Experimental Rat Models [J].

Guada, Melissa ;

Ganugula, Raghu ;

Vadhanam, Manicka ;

Kumar, Majeti N. V. Ravi .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2017, 363 (01) :58-65

[29] Gut dysbiosis and age-related neurological diseases; an innovative approach for therapeutic interventions [J].

Holmes, Aleah ;

Finger, Carson ;

Morales-Scheihing, Diego ;

Lee, Juneyoung ;

Mccullough, Louise D. .

TRANSLATIONAL RESEARCH, 2020, 226 :39-56

[30] Global epidemiology and outcomes of acute kidney injury [J].

Hoste, Eric A. J. ;

Kellum, John A. ;

Selby, Nicholas M. ;

Zarbock, Alexander ;

Palevsky, Paul M. ;

Bagshaw, Sean M. ;

Goldstein, Stuart L. ;

Cerda, Jorge ;

Chawla, Lakhmir S. .

NATURE REVIEWS NEPHROLOGY, 2018, 14 (10) :607-625

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