Field triage to primary angioplasty combined with emergency department bypass reduces treatment delays and is associated with improved outcome

被引:102
作者
Carstensen, Steen [1 ]
Nelson, Greg C. I.
Hansen, Peter S.
Macken, Lewis
Irons, Stephen
Flynn, Michael
Kovoor, Pramesh
Hoo, Soon Y. Soo
Ward, Michael R.
Rasmussen, Heige H.
机构
[1] Univ Sydney, Royal N Shore Hosp, Dept Cardiol, Sydney, NSW 2006, Australia
[2] Univ Sydney, Royal N Shore Hosp, Dept Emergency, Sydney, NSW 2006, Australia
[3] Ambulance Ser New S Wales, Sydney, NSW, Australia
[4] Univ Sydney, Westmead Hosp, Dept Cardiol, Sydney, NSW 2006, Australia
关键词
myocardial infarction; treatment pathway; primary angioplasty; mortality;
D O I
10.1093/eurheartj/ehm306
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims We investigated the net benefit in the outcome of reducing treatment delay through field triage and emergency department (ED) bypass in patients with ST-elevation myocardial infarction (STEMI) treated with primary angioplasty. Methods and results In a prospective registry study, consecutive patients with suspected STEM] were assigned to: (i) pre-hospital ECG and triage or (ii) ECG and triage at the closest ED, solely based on ambulance availability. Four district hospitals and one regional heart centre serviced the 890 000 population metropolitan area and primary angioplasty was the only reperfusion strategy employed. Baseline characteristics were similar in STEMI patients triaged in the field (108) and the EDs (193). Symptom onset to balloon times: 154 [inter-quartile range (IQR) 120-233) vs. 249 (IQR 184-405) min (P < 0.001) and peak creatine kinase in early presenters (<2 h): 1435 (95 %CI: 904-1966) U/L vs. 2320 (95% CI: 1881-2762) U/L (P = 0.009) were tower in field- than in ED-triaged patients. Mortality in the PCI treated were 1.1 and 8.2% [P = 0.025, RR 0.14 (95% Cl: 0.01-1.08)] and overall mortality were 1.9 and 7.3% [P = 0.046, RR 0.26 (95% CI: 0.05-1.11)]. Conclusion Field-triage and ED bypass were feasible means of reducing treatment delay in patients with suspected STEMI and resulted in smaller infarct size in early presenters and a trend towards a reduction in mortality.
引用
收藏
页码:2313 / 2319
页数:7
相关论文
共 26 条
  • [11] THROMBOLYSIS AND MYOCARDIAL SALVAGE - RESULTS OF CLINICAL-TRIALS AND THE ANIMAL PARADIGM - PARADOXIC OR PREDICTABLE
    GERSH, BJ
    ANDERSON, JL
    [J]. CIRCULATION, 1993, 88 (01) : 296 - 306
  • [12] The quantification of infarct size
    Gibbons, RJ
    Valeti, US
    Araoz, PA
    Jaffe, AS
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 44 (08) : 1533 - 1542
  • [13] Haase Jurgen, 2004, J Interv Cardiol, V17, P367, DOI 10.1111/j.1540-8183.2004.04078.x
  • [14] Prevalence of coronary occlusion and outcome of an immediate invasive strategy in suspected acute myocardial infarction with and without ST-segment elevation
    Koyama, Y
    Hansen, PS
    Hanratty, CG
    Nelson, GIC
    Rasmussen, HH
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 2002, 90 (06) : 579 - 584
  • [15] Influence of treatment delay on infarct size and clinical outcome in patients with acute myocardial infarction treated with primary angioplasty
    Liem, AL
    van't Hof, AWJ
    Hoorntje, JCA
    de Boer, MJ
    Suryapranata, H
    Zijlstra, F
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1998, 32 (03) : 629 - 633
  • [16] Relationship between time of day, day of week, timeliness of reperfusion, and in-hospital mortality for patients with acute ST-segment elevation myocardial infarction
    Magid, DJ
    Wang, YF
    Herrin, J
    McNamara, RL
    Bradley, EH
    Curtis, JP
    Pollack, CV
    French, WJ
    Blaney, ME
    Krumholz, HM
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 294 (07): : 803 - 812
  • [17] Time to therapy and salvage in myocardial infarction
    Milavetz, JJ
    Giebel, DW
    Christian, TF
    Schwartz, RS
    Holmes, DR
    Gibbons, RJ
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1998, 31 (06) : 1246 - 1251
  • [18] Clinical impact of direct referral to primary percutaneous coronary intervention following pre-hospital diagnosis of ST-elevation myocardial infarction
    Ortolani, Paolo
    Marzocchi, Antonio
    Marrozzini, Cinzia
    Palmerini, Tullio
    Saia, Francesco
    Serantoni, Carlo
    Aquilina, Matteo
    Silenzi, Simona
    Baldazzi, Federica
    Grosseto, Daniele
    Taglieri, Nevio
    Cooke, Robin M. T.
    Bacchi-Reggiani, Maria Letizia
    Branzi, Angelo
    [J]. EUROPEAN HEART JOURNAL, 2006, 27 (13) : 1550 - 1557
  • [19] Therapy-dependent influence of time-to-treatment interval on myocardial salvage in patients with acute myocardial infarction treated with coronary artery stenting or thrombolysis
    Schömig, A
    Ndrepepa, G
    Mehilli, J
    Schwaiger, M
    Schühlen, H
    Nekolla, S
    Pache, J
    Martinoff, S
    Bollwein, H
    Kastrati, A
    [J]. CIRCULATION, 2003, 108 (09) : 1084 - 1088
  • [20] Impact of time to treatment on mortality after prehospital fibrinolysis or primary angioplasty - Data from the CAPTIM randomized clinical trial
    Steg, PG
    Bonnefoy, E
    Chabaud, S
    Lapostolle, F
    Dubien, PY
    Cristofini, P
    Leizorovicz, A
    Touboul, P
    [J]. CIRCULATION, 2003, 108 (23) : 2851 - 2856