Inflammation and cancer: macrophage migration inhibitory factor (MIF)-the potential missing link

被引：170
作者：
Conroy, H. [1 ]
Mawhinney, L. [1 ]
Donnelly, S. C. [1 ]
机构：
[1] Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Sch Med & Med Sci, Dublin 4, Ireland
来源：
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE | 2010年 / 103卷 / 11期
关键词：
ENDOTHELIAL GROWTH-FACTOR; ACTIVATED PROTEIN-KINASE; FACTOR MIF; REGULATORY ROLE; COLORECTAL-CANCER; BREAST-CANCER; RHEUMATOID-ARTHRITIS; DISEASE SEVERITY; ANGIOGENESIS; HYPOXIA;
D O I：
10.1093/qjmed/hcq148
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Macrophage migration inhibitory factor (MIF) was the original cytokine, described almost 50 years ago and has since been revealed to be an important player in pro-inflammatory diseases. Recent work using MIF mouse models has revealed new roles for MIF. In this review, we present an increasing body of evidence implicating the key pro-inflammatory cytokine MIF in specific biological activities related directly to cancer growth or contributing towards a microenvironment favouring cancer progression.
引用
收藏
页码：831 / 836
页数：6
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