Inflammation and cancer: macrophage migration inhibitory factor (MIF)-the potential missing link

被引：170

作者：

Conroy, H. ^{[1
]}

Mawhinney, L. ^{[1
]}

Donnelly, S. C. ^{[1
]}

机构：

[1] Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Sch Med & Med Sci, Dublin 4, Ireland

来源：

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE | 2010年 / 103卷 / 11期

关键词：

ENDOTHELIAL GROWTH-FACTOR; ACTIVATED PROTEIN-KINASE; FACTOR MIF; REGULATORY ROLE; COLORECTAL-CANCER; BREAST-CANCER; RHEUMATOID-ARTHRITIS; DISEASE SEVERITY; ANGIOGENESIS; HYPOXIA;

D O I：

10.1093/qjmed/hcq148

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Macrophage migration inhibitory factor (MIF) was the original cytokine, described almost 50 years ago and has since been revealed to be an important player in pro-inflammatory diseases. Recent work using MIF mouse models has revealed new roles for MIF. In this review, we present an increasing body of evidence implicating the key pro-inflammatory cytokine MIF in specific biological activities related directly to cancer growth or contributing towards a microenvironment favouring cancer progression.

引用

页码：831 / 836

页数：6

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