A Placebo-Controlled Trial of Atomoxetine in Marijuana-Dependent Individuals with Attention Deficit Hyperactivity Disorder

被引：59

作者：

McRae-Clark, Aimee L. ^{[1
]}

Carter, Rickey E. ^{[2
]}

Killeen, Therese K. ^{[1
]}

Carpenter, Matthew J. ^{[1
]}

White, Kathleen G. ^{[1
]}

Brady, Kathleen T. ^{[1
]}

机构：

[1] Med Univ S Carolina, Dept Psychiat & Behav Sci, Charleston, SC 29425 USA

[2] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA

来源：

AMERICAN JOURNAL ON ADDICTIONS | 2010年 / 19卷 / 06期

关键词：

DEFICIT/HYPERACTIVITY DISORDER; SUBSTANCE-ABUSE; ADULT ADHD; SUBTHRESHOLD DIAGNOSES; LATE-ONSET; FOLLOW-UP; ALCOHOL; METHYLPHENIDATE; COMORBIDITY; COGNITION;

D O I：

10.1111/j.1521-0391.2010.00076.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

This study evaluated the effects of atomoxetine on the symptoms of attention deficit hyperactivity disorder (ADHD) and marijuana use in marijuana-dependent adults. In conjunction with motivational interviewing, participants received either atomoxetine (n = 19) or matching placebo (n = 19) for 12 weeks. Participants randomized to atomoxetine had greater improvement in ADHD on the Clinical Global Impression-Improvement scale than participants treated with placebo. No treatment group differences in self-rated ADHD symptoms, overall Wender-Reimherr Adult Attention Deficit Disorder Scale scores, or marijuana use outcomes were noted. These results suggest that atomoxetine may improve some ADHD symptoms but does not reduce marijuana use in this population. (Am J Addict 2010;00:1-9).

引用

页码：481 / 489

页数：9

共 48 条

[1] Comparative Epidemiology of Dependence on Tobacco, Alcohol, Controlled Substances, and Inhalants: Basic Findings From the National Comorbidity Survey [J].

Anthony, James C. ;

Warner, Lynn A. ;

Kessler, Ronald C. .

EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY, 1994, 2 (03) :244-268

[2] Validity of the age-of-onset criterion for ADHD: A report from the DSM-IV field trials [J].

Applegate, B ;

Lahey, BB ;

Hart, EL ;

Biederman, J ;

Hynd, GW ;

Barkley, RA ;

Ollendick, T ;

Frick, PJ ;

Greenhill, L ;

McBurnett, K ;

Newcorn, JH ;

Kerdyk, L ;

Garfinkel, B ;

Waldman, I ;

Shaffer, D .

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1997, 36 (09) :1211-1221

[3]

Barkley R.A., 2006, ATTENTION DEFICIT HY, V3rd, P248

[4]

BIEDERMAN J, 1995, AM J PSYCHIAT, V152, P1652

[5]

Biederman J, 2003, J CLIN PSYCHIAT, V64, P3

[6]

BIEDERMAN J, 1993, AM J PSYCHIAT, V150, P1792

[7] Does attention-deficit hyperactivity disorder impact the developmental course of drug and alcohol abuse and dependence? [J].

Biederman, J ;

Wilens, TE ;

Mick, E ;

Faraone, SV ;

Spencer, T .

BIOLOGICAL PSYCHIATRY, 1998, 44 (04) :269-273

[8]

Conners C. K., 1999, CONNERSADULT ADHD RA

[9]

Faraone SV, 2007, J CLIN PSYCHIAT, V68, P15

[10] Neuropsychological studies of late onset and subthreshold diagnoses of adult attention-deficit/hyperactivity disorder [J].

Faraone, Stephen V. ;

Biederman, Joseph ;

Doyle, Alysa ;

Murray, Kate ;

Petty, Carter ;

Adamson, Joel J. ;

Seidman, Larry .

BIOLOGICAL PSYCHIATRY, 2006, 60 (10) :1081-1087

← 1 2 3 4 5 →