Effect of pH and cations on the formation and structure of human telomeric G-quadruplex DNA

被引：0
|
作者：
Zhou Jiang [1 ]
Yuan Gu
机构：
[1] Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
[2] Peking Univ, Coll Chem & Mol Engn, Dept Biol Chem, Key Lab Bioorgan Chem & Mol Engn,Minist Educ, Beijing 100871, Peoples R China
来源：
ACTA CHIMICA SINICA | 2007年 / 65卷 / 16期
关键词：
telomere; G-quadruplex DNA; ESI mass spectrometry; circular dichroism;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Electrospray ionization mass spectrometry and circular dichroism were used to investigate the factors which affect the motif of the human telomeric quadruplex, such as pH and cations. ESI-MS and CD spectra indicated that pH could induce both the conformational transition and the dissociation of the quadruplex. Moreover, K+ and NH4+ cations play an important role in the formation of the quadruplex.
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收藏
页码：1728 / 1732
页数：5
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