Identification of a novel DRB1 allele, DRB1*1112, by sequence-based DRB typing

被引：4

作者：

Luo, M

Blanchard, J

Maclean, I

Brunham, R

机构：

[1] Univ British Columbia, Ctr Dis Control, Vancouver, BC V5Z 4R4, Canada

[2] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB, Canada

来源：

TISSUE ANTIGENS | 2001年 / 57卷 / 01期

关键词：

HLA-DRB1; allele; DRB1*1112;

D O I：

10.1034/j.1399-0039.2001.057001085.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We report here a novel DRB1 allele (DRB1*1112) identified during sequence-based HLA-DRB typing. Polymerase chain reaction with generic DRB primers and group-specific primers and subsequent sequencing yielded identical results. Molecular cloning and sequencing confirmed that the new DRB1 allele is identical to DRB1*11011 and 1129 at exon 2 except for a single nucleotide substitution at codon 37, changing the codon from Tyr (DRB1*11011) or Ser (DRB1*1129) to Phe.

引用

页码：85 / 86

页数：2