Nucleic Acid/Organic Polymer Hybrid Materials: Synthesis, Superstructures, and Applications

被引:122
作者
Kwak, Minseok [1 ]
Herrmann, Andreas [1 ]
机构
[1] Univ Groningen, Dept Polymer Chem, Zernike Inst Adv Mat, NL-9747 AG Groningen, Netherlands
关键词
biomaterials; block copolymers; DNA; drug delivery; nanostructures; BLOCK-COPOLYMER MICELLES; POLYELECTROLYTE COMPLEX MICELLES; DOUBLE-STRANDED DNA; ANTIVIRAL ACTIVITY; ANTISENSE OLIGONUCLEOTIDES; MESSENGER-RNA; POLYPHENYLENE DENDRIMERS; AFFINITY PRECIPITATION; DNA/POLYMER CONJUGATE; RESPONSIVE HYDROGELS;
D O I
10.1002/anie.200906820
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Extensive efforts have been devoted to the development of hybrid structures consisting of biomacromolecules and organic polymers connected through covalent bonds. While the combination of proteins and peptides with synthetic macromolecules has been explored in depth, far fewer examples of nucleic acid/polymer hybrids are known. In this Review we give selected examples of this exciting class of materials which can be arranged as linear block copolymer architectures, as side-chain polymers, or as cross-linked networks. Emphasis is placed on the fabrication of these materials as well as on their potential applications in nanoscience, diagnostics, and biomedicine. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码:8574 / 8587
页数:14
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