Acetyl-l-carnitine protects yeast cells from apoptosis and aging and inhibits mitochondrial fission

被引：38

作者：

Palermo, Vanessa ^{[1
]}

Falcone, Claudio ^{[1
]}

Calvani, Menotti ^{[2
]}

Mazzoni, Cristina ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Cell & Dev Biol, Inst Pasteur, Cenci Bolognetti Fdn, I-00185 Rome, Italy

[2] Sigma Tau Pharmaceut Co, Dept Sci, Rome, Italy

来源：

AGING CELL | 2010年 / 9卷 / 04期

关键词：

aging; apoptosis; carnitine; mitochondria; S; cerevisiae; CALORIE RESTRICTION EXTENDS; SACCHAROMYCES-CEREVISIAE; MULTICOPY SUPPRESSOR; REGULATES APOPTOSIS; S; CEREVISIAE; LIFE-SPAN; GENE; MEMBRANE; FUSION; STRESS;

D O I：

10.1111/j.1474-9726.2010.00587.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

P>In this work we report that carnitines, in particular acetyl-l-carnitine (ALC), are able to prolong the chronological aging of yeast cells during the stationary phase. Lifespan extension is significantly reduced in yca1 mutants as well in rho0 strains, suggesting that the protective effects pass through the Yca1 caspase and mitochondrial functions. ALC can also prevent apoptosis in pro-apoptotic mutants, pointing to the importance of mitochondrial functions in regulating yeast apoptosis and aging. We also demonstrate that ALC attenuates mitochondrial fission in aged yeast cells, indicating a correlation between its protective effect and this process. Our findings suggest that ALC, used as therapeutic for stroke, myocardial infarction and neurodegenerative diseases, besides the well-known anti-oxidant effects, might exert protective effects also acting on mitochondrial morphology.

引用

页码：570 / 579

页数：10

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