Production and characterisation of highly concentrated nanosuspensions by high pressure homogenisation

被引：79

作者：

Krause, KP ^{[1
]}

Müller, RH ^{[1
]}

机构：

[1] Free Univ Berlin, Dept Pharmaceut Biopharmaceut & Biotechnol, D-12169 Berlin, Germany

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2001年 / 214卷 / 1-2期

关键词：

nanosuspensions; high concentration; high pressure homogenisation; surfactants;

D O I：

10.1016/S0378-5173(00)00626-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nanosuspensions produced by high-pressure homogenisation are a solution for the formulation of poorly soluble drugs with bioavailability problems. The typical solid concentration of the nanosuspensions is 10%. However, to transfer the nanosuspensions to a dry product (e.g. granulation, tablets, pellets), a higher solid content is required to remove less water. Nanosuspensions with 20 and 30%, solid content were produced, the effect of surfactant concentration assessed and their quality (size data) compared with the lower standard concentrations of 1-10% solid. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：21 / 24

页数：4