Pathogenic Role of IL-17-Producing Immune Cells in Obesity, and Related Inflammatory Diseases

被引：138

作者：

Chehimi, Marwa ^{[1
]}

Vidal, Hubert ^{[1
]}

Eljaafari, Assia ^{[1
,2
]}

机构：

[1] Univ Claude Bernard Lyon 1, INRA, Charles Merieux Med Sch,CarMeN Lab, INSA Lyon,Inserm,U1060,U1397, F-69600 Oullins, France

[2] Ctr Hosp Lyon Sud, Hosp Civils Lyon, Dept Clin Res, F-69495 Pierre Benite, France

来源：

JOURNAL OF CLINICAL MEDICINE | 2017年 / 6卷 / 07期

关键词：

obesity; IL-17-producing T (IL-17) cells; adipose-derived-stem-cells; inflammatory diseases; immuno-metabolism; INNATE LYMPHOID-CELLS; COLLAGEN-INDUCED ARTHRITIS; GROWTH-FACTOR-BETA; CD4(+) T-CELLS; ROR-GAMMA-T; ADIPOSE-TISSUE; INSULIN-RESISTANCE; REGULATORY T; TNF-ALPHA; TH17; CELLS;

D O I：

10.3390/jcm6070068

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity is associated with low-grade chronic inflammation. Indeed, adipose tissues (AT) in obese individuals are the former site of progressive infiltration by pro-inflammatory immune cells, which together with increased inflammatory adipokine secretion induce adipocyte insulin resistance. IL-17-producing T (Th17) cells are part of obese AT infiltrating cells, and are likely to be promoted by adipose tissue-derived mesenchymal stem cells, as previously reported by our team. Whereas Th17 cell are physiologically implicated in the neutralization of fungal and bacterial pathogens through activation of neutrophils, they may also play a pivotal role in the onset and/or progression of chronic inflammatory diseases, or cancer, in which obesity is recognized as a risk factor. In this review, we will highlight the pathogenic role of IL-17A producing cells in the mechanisms leading to inflammation in obesity and to progression of obesity-related inflammatory diseases.

引用

页数：19

共 140 条

[81] Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer [J].

Miyahara, Yoshihiro ;

Odunsi, Kunle ;

Chen, Wenhao ;

Peng, Guangyong ;

Matsuzaki, Junko ;

Wang, Rong-Fu .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (40) :15505-15510

[82] Induced IL-17-Producing Invariant NKT Cells Require Activation in Presence of TGF-β and IL-1β [J].

Monteiro, Marta ;

Almeida, Catarina F. ;

Agua-Doce, Ana ;

Graca, Luis .

JOURNAL OF IMMUNOLOGY, 2013, 190 (02) :805-811

[83] Proinflammatory Environment Dictates the IL-17-Producing Capacity of Human Invariant NKT Cells [J].

Moreira-Teixeira, Lucia ;

Resende, Mariana ;

Coffre, Maryaline ;

Devergne, Odile ;

Herbeuval, Jean-Philippe ;

Hermine, Olivier ;

Schneider, Elke ;

Rogge, Lars ;

Ruemmele, Frank M. ;

Dy, Michel ;

Cordeiro-da-Silva, Anabela ;

Leite-de-Moraes, Maria C. .

JOURNAL OF IMMUNOLOGY, 2011, 186 (10) :5758-5765

[84] Tumor-specific Th17-polarized cells eradicate large established melanoma [J].

Muranski, Pawel ;

Boni, Andrea ;

Antony, Paul A. ;

Cassard, Lydie ;

Irvine, Kari R. ;

Kaiser, Andrew ;

Paulos, Chrystal M. ;

Palmer, Douglas C. ;

Touloukian, Christopher E. ;

Ptak, Krzysztof ;

Gattinoni, Luca ;

Wrzesinski, Claudia ;

Hinrichs, Christian S. ;

Kerstann, Keith W. ;

Feigenbaum, Lionel ;

Chan, Chi-Chao ;

Restifo, Nicholas P. .

BLOOD, 2008, 112 (02) :362-373

[85] Protective and pathogenic functions of macrophage subsets [J].

Murray, Peter J. ;

Wynn, Thomas A. .

NATURE REVIEWS IMMUNOLOGY, 2011, 11 (11) :723-737

[86] Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013 [J].

Ng, Marie ;

Fleming, Tom ;

Robinson, Margaret ;

Thomson, Blake ;

Graetz, Nicholas ;

Margono, Christopher ;

Mullany, Erin C. ;

Biryukov, Stan ;

Abbafati, Cristiana ;

Abera, Semaw Ferede ;

Abraham, Jerry P. ;

Abu-Rmeileh, Niveen M. E. ;

Achoki, Tom ;

AlBuhairan, Fadia S. ;

Alemu, Zewdie A. ;

Alfonso, Rafael ;

Ali, Mohammed K. ;

Ali, Raghib ;

Alvis Guzman, Nelson ;

Ammar, Walid ;

Anwari, Palwaslia ;

Banerjee, Amitava ;

Barquera, Simon ;

Basu, Sanjay ;

Bennett, Derrick A. ;

Bhutta, Zulfiqar ;

Blore, Jed ;

Cabral, Norberto ;

Campos Nonato, Ismael ;

Chang, Jung-Chen ;

Chowdhury, Rajiv ;

Courville, Karen J. ;

Criqui, Michael H. ;

Cundiff, David K. ;

Dabhadkar, Kaustubh C. ;

Dandona, Lalit ;

Davis, Adrian ;

Dayama, Anand ;

Dharmaratne, Samath D. ;

Ding, Eric L. ;

Durrani, Adnan M. ;

Esteghamati, Alireza ;

Farzadfar, Farshad ;

Fay, Derek F. J. ;

Feigin, Valery L. ;

Flaxman, Abraham ;

Forouzanfar, Mohammad H. ;

Goto, Atsushi ;

Green, Mark A. ;

Gupta, Rajeev .

LANCET, 2014, 384 (9945) :766-781

[87] CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity [J].

Nishimura, Satoshi ;

Manabe, Ichiro ;

Nagasaki, Mika ;

Eto, Koji ;

Yamashita, Hiroshi ;

Ohsugi, Mitsuru ;

Otsu, Makoto ;

Hara, Kazuo ;

Ueki, Kohjiro ;

Sugiura, Seiryo ;

Yoshimura, Kotaro ;

Kadowaki, Takashi ;

Nagai, Ryozo .

NATURE MEDICINE, 2009, 15 (08) :914-U116

[88] Interleukin-17 promotes angiogenesis and tumor growth [J].

Numasaki, M ;

Fukushi, J ;

Ono, M ;

Narula, SK ;

Zavodny, PJ ;

Kudo, T ;

Robbins, PD ;

Tahara, H ;

Lotze, MT .

BLOOD, 2003, 101 (07) :2620-2627

[89] Pleiotropic Actions of Insulin Resistance and Inflammation in Metabolic Homeostasis [J].

Odegaard, Justin I. ;

Chawla, Ajay .

SCIENCE, 2013, 339 (6116) :172-177

[90] Adipokines in inflammation and metabolic disease [J].

Ouchi, Noriyuki ;

Parker, Jennifer L. ;

Lugus, Jesse J. ;

Walsh, Kenneth .

NATURE REVIEWS IMMUNOLOGY, 2011, 11 (02) :85-97

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