NOTCH TARGETS AND THEIR REGULATION

被引：128

作者：

Bray, Sarah ^{[1
]}

Bernard, Fred ^{[1
]}

机构：

[1] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge, England

来源：

NOTCH SIGNALING | 2010年 / 92卷

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

SPLIT COMPLEX GENES; ENHANCER-OF-SPLIT; SIGNAL-TRANSDUCTION PATHWAY; ELEGANS VULVAL DEVELOPMENT; TUMOR-SUPPRESSOR ACTIVITY; HEY BHLH FACTORS; TRANSCRIPTIONAL REPRESSION; C-ELEGANS; DROSOPHILA-MELANOGASTER; FUNCTIONAL INTERACTION;

D O I：

10.1016/S0070-2153(10)92008-5

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The proteolytic cleavages elicited by activation of the Notch receptor release an intracellular fragment, Notch intracellular domain, which enters the nucleus to activate the transcription of targets. Changes in transcription are therefore a major output of this pathway. However, the Notch outputs clearly differ from cell type to cell type. In this review we discuss current understanding of Notch targets, the mechanisms involved in their transcriptional regulation, and what might underlie the activation of different sets of targets in different cell types.

引用

页码：253 / 275

页数：23

共 153 条

[21] Drosophila Stem Cells Share a Common Requirement for the Histone H2B Ubiquitin Protease Scrawny [J].

Buszczak, Michael ;

Paterno, Shelley ;

Spradling, Allan C. .

SCIENCE, 2009, 323 (5911) :248-251

[22] Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling [J].

Campese, Antonio F. ;

Garbe, Annette I. ;

Zhang, Fangrong ;

Grassi, Fabio ;

Screpanti, Isabella ;

von Boehmer, Harald .

BLOOD, 2006, 108 (01) :305-310

[23] Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless [J].

Castro, B ;

Barolo, S ;

Bailey, AM ;

Posakony, JW .

DEVELOPMENT, 2005, 132 (15) :3333-3344

[24] A DNA transcription code for cell-specific gene activation by Notch signaling [J].

Cave, JW ;

Loh, F ;

Surpris, JW ;

Xia, L ;

Caudy, MA .

CURRENT BIOLOGY, 2005, 15 (02) :94-104

[25] MHC recognition in thymic development: Distinct, parallel pathways for survival and lineage commitment [J].

Chang, D ;

Valdez, P ;

Ho, T ;

Robey, E .

JOURNAL OF IMMUNOLOGY, 2000, 165 (12) :6710-6715

[26] A functional interaction between the histone deacetylase Rpd3 and the corepressor Groucho in Drosophila development [J].

Chen, GQ ;

Fernandez, J ;

Mische, S ;

Courey, AJ .

GENES & DEVELOPMENT, 1999, 13 (17) :2218-2230

[27] Regulation of the ERBB-2 promoter by RBPJ kappa and NOTCH [J].

Chen, YY ;

Fischer, WH ;

Gill, GN .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (22) :14110-14114

[28] γ-Secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney [J].

Cheng, HT ;

Miner, JH ;

Lin, MH ;

Tansey, MG ;

Roth, K ;

Kopan, R .

DEVELOPMENT, 2003, 130 (20) :5031-5042

[29] Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron [J].

Cheng, Hui-Teng ;

Kim, Mijin ;

Valerius, M. Todd ;

Surendran, Kameswaran ;

Schuster-Gossler, Karin ;

Gossler, Achim ;

McMahon, Andrew P. ;

Kopan, Raphael .

DEVELOPMENT, 2007, 134 (04) :801-811

[30]

Chopra VS, 2009, CURR BIOL, V19, P688, DOI 10.1016/j.cub.2009.02.055

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