NOTCH TARGETS AND THEIR REGULATION

被引：125
作者：
Bray, Sarah [1 ]
Bernard, Fred [1 ]
机构：
[1] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge, England
来源：
NOTCH SIGNALING | 2010年 / 92卷
基金：
英国生物技术与生命科学研究理事会; 英国医学研究理事会;
关键词：
SPLIT COMPLEX GENES; ENHANCER-OF-SPLIT; SIGNAL-TRANSDUCTION PATHWAY; ELEGANS VULVAL DEVELOPMENT; TUMOR-SUPPRESSOR ACTIVITY; HEY BHLH FACTORS; TRANSCRIPTIONAL REPRESSION; C-ELEGANS; DROSOPHILA-MELANOGASTER; FUNCTIONAL INTERACTION;
D O I：
10.1016/S0070-2153(10)92008-5
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The proteolytic cleavages elicited by activation of the Notch receptor release an intracellular fragment, Notch intracellular domain, which enters the nucleus to activate the transcription of targets. Changes in transcription are therefore a major output of this pathway. However, the Notch outputs clearly differ from cell type to cell type. In this review we discuss current understanding of Notch targets, the mechanisms involved in their transcriptional regulation, and what might underlie the activation of different sets of targets in different cell types.
引用
收藏
页码：253 / 275
页数：23
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