NOTCH TARGETS AND THEIR REGULATION

被引：125
作者：
Bray, Sarah [1 ]
Bernard, Fred [1 ]
机构：
[1] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge, England
来源：
NOTCH SIGNALING | 2010年 / 92卷
基金：
英国生物技术与生命科学研究理事会; 英国医学研究理事会;
关键词：
SPLIT COMPLEX GENES; ENHANCER-OF-SPLIT; SIGNAL-TRANSDUCTION PATHWAY; ELEGANS VULVAL DEVELOPMENT; TUMOR-SUPPRESSOR ACTIVITY; HEY BHLH FACTORS; TRANSCRIPTIONAL REPRESSION; C-ELEGANS; DROSOPHILA-MELANOGASTER; FUNCTIONAL INTERACTION;
D O I：
10.1016/S0070-2153(10)92008-5
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The proteolytic cleavages elicited by activation of the Notch receptor release an intracellular fragment, Notch intracellular domain, which enters the nucleus to activate the transcription of targets. Changes in transcription are therefore a major output of this pathway. However, the Notch outputs clearly differ from cell type to cell type. In this review we discuss current understanding of Notch targets, the mechanisms involved in their transcriptional regulation, and what might underlie the activation of different sets of targets in different cell types.
引用
收藏
页码：253 / 275
页数：23
相关论文
共 153 条
  • [1] Network motifs: theory and experimental approaches
    Alon, Uri
    [J]. NATURE REVIEWS GENETICS, 2007, 8 (06) : 450 - 461
  • [2] Alper S, 2001, DEVELOPMENT, V128, P1793
  • [3] Direct regulation of Gata3 expression determines the T helper differentiation potential of notch
    Amsen, Derk
    Antov, Andrey
    Jankovic, Dragana
    Sher, Alan
    Radtke, Freddy
    Souabni, Abdallah
    Busslinger, Meinrad
    McCright, Brent
    Gridley, Thomas
    Flavell, Richard A.
    [J]. IMMUNITY, 2007, 27 (01) : 89 - 99
  • [4] Single-minded, Dmef2, Pointed, and Su(H) act on identified regulatory sequences of the roughest gene in Drosophila melanogaster
    Apitz, H
    Strünkelnberg, M
    de Couet, HG
    Fischbach, KF
    [J]. DEVELOPMENT GENES AND EVOLUTION, 2005, 215 (09) : 460 - 469
  • [5] Genetic screens for enhancers of brahma reveal functional interactions between the BRM chromatin-remodeling complex and the Delta-Notch signal transduction pathway in Drosophila
    Armstrong, JA
    Sperling, AS
    Deuring, R
    Manning, L
    Moseley, SL
    Papoulas, O
    Piatek, CI
    Doe, CQ
    Tamkun, JW
    [J]. GENETICS, 2005, 170 (04) : 1761 - 1774
  • [6] Transcriptional enhancers: Intelligent enhanceosomes or flexible billboards?
    Arnosti, DN
    Kulkarni, MM
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 2005, 94 (05) : 890 - 898
  • [7] Notch and Ras signaling pathway effector genes expressed in fusion competent and founder cells during Drosophila myogenesis
    Artero, R
    Furlong, EE
    Beckett, K
    Scott, MP
    Baylies, M
    [J]. DEVELOPMENT, 2003, 130 (25): : 6257 - 6272
  • [8] SUPPRESSOR OF HAIRLESS DIRECTLY ACTIVATES TRANSCRIPTION OF ENHANCER OF SPLIT COMPLEX GENES IN RESPONSE TO NOTCH RECEPTOR ACTIVITY
    BAILEY, AM
    POSAKONY, JW
    [J]. GENES & DEVELOPMENT, 1995, 9 (21) : 2609 - 2622
  • [9] Transcriptional control of stem cell maintenance in the Drosophila intestine
    Bardin, Allison J.
    Perdigoto, Carolina N.
    Southall, Tony D.
    Brand, Andrea H.
    Schweisguth, Francois
    [J]. DEVELOPMENT, 2010, 137 (05): : 705 - 714
  • [10] A notch-independent activity of suppressor of hairless is required for normal mechanoreceptor physiology
    Barolo, S
    Walker, RG
    Polyanovsky, AD
    Freschi, G
    Keil, T
    Posakony, JW
    [J]. CELL, 2000, 103 (06) : 957 - 969
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