Unravelling the activation mechanisms of protein kinase B/Akt

被引：337

作者：

Scheid, MP ^{[1
]}

Woodgett, JR ^{[1
]}

机构：

[1] Ontario Canc Inst, Toronto, ON M5G 2M9, Canada

来源：

FEBS LETTERS | 2003年 / 546卷 / 01期

关键词：

protein kinase; signal transduction; protein kinase B; Akt; 3-phosphoinositide-dependent kinase-1; phosphatidylinositol; 3-kinase;

D O I：

10.1016/S0014-5793(03)00562-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Over the past decade, protein kinase B (PKB, also termed Akt) has emerged as an important signaling mediator between extracellular cues and modulation of gene expression, metabolism, and cell survival. The enzyme is tightly controlled and consequences of its deregulation include loss of growth control and oncogenesis. Recent work has better characterized the mechanism of PKB activation, including upstream regulators and secondary binding partners. This minireview refreshes some old concepts with new twists and highlights current outstanding questions. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

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页码：108 / 112

页数：5

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