In Vitro Activity of a Novel Glucan Synthase Inhibitor, SCY-078, against Clinical Isolates of Candida auris

被引：83

作者：

Berkow, Elizabeth L. ^{[1
]}

Angulo, David ^{[2
]}

Lockhart, Shawn R. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA USA

[2] SCYNEXIS Inc, Jersey City, NJ USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 07期

关键词：

Candida auris; SCY-078; MK-3118;

D O I：

10.1128/AAC.00435-17

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

引用

页数：2

共 8 条

[1] Multidrug-resistant Candida auris: 'new kid on the block' in hospital-associated infections? [J].

Chowdhary, A. ;

Voss, A. ;

Meis, J. F. .

JOURNAL OF HOSPITAL INFECTION, 2016, 94 (03) :209-212

[2]

CLSI, 2008, REF METH BROTH DIL A, V28

[3] Enfumafungin Derivative MK-3118 Shows Increased In Vitro Potency against Clinical Echinocandin-Resistant Candida Species and Aspergillus Species Isolates [J].

Jimenez-Ortigosa, Cristina ;

Paderu, Padmaja ;

Motyl, Mary R. ;

Perlin, David S. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (02) :1248-1251

[4]

Larkin E, 2017, ANTIMICROB AGENTS CH, V61, DOI [10.1128/AAC.02396-16, 10.1128/aac.02396-16]

[5] Pharmacodynamic Target Evaluation of a Novel Oral Glucan Synthase Inhibitor, SCY-078 (MK-3118), Using an In Vivo Murine Invasive Candidiasis Model [J].

Lepak, Alexander J. ;

Marchillo, Karen ;

Andes, David R. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (02) :1265-1272

[6] Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses [J].

Lockhart, Shawn R. ;

Etienne, Kizee A. ;

Vallabhaneni, Snigdha ;

Farooqi, Joveria ;

Chowdhary, Anuradha ;

Govender, Nelesh P. ;

Colombo, Arnaldo Lopes ;

Calvo, Belinda ;

Cuomo, Christina A. ;

Desjardins, Christopher A. ;

Berkow, Elizabeth L. ;

Castanheira, Mariana ;

Magobo, Rindidzani E. ;

Jabeen, Kauser ;

Asghar, Rana J. ;

Meis, Jacques F. ;

Jackson, Brendan ;

Chiller, Tom ;

Litvintseva, Anastasia P. .

CLINICAL INFECTIOUS DISEASES, 2017, 64 (02) :134-140

[7] Activity of MK-3118, a new oral glucan synthase inhibitor, tested against Candida spp. by two international methods (CLSI and EUCAST) [J].

Pfaller, Michael A. ;

Messer, Shawn A. ;

Motyl, Mary R. ;

Jones, Ronald N. ;

Castanheira, Mariana .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2013, 68 (04) :858-863

[8]

Vallabhaneni S, 2016, MMWR-MORBID MORTAL W, V65, P1234, DOI [10.15585/mmwr.mm6544e1, 10.1111/ajt.14121]

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