Role of defective Ca2+ signaling in skeletal muscle weakness: Pharmacological implications

被引：51
作者：
Agrawal, Akanksha [1 ]
Suryakumar, Geetha [1 ]
Rathor, Richa [1 ]
机构：
[1] DRDO, Def Inst Physiol & Allied Sci, Lucknow Rd, Delhi 110054, India
来源：
JOURNAL OF CELL COMMUNICATION AND SIGNALING | 2018年 / 12卷 / 04期
关键词：
Calcium; Ryanodine receptor; RyR1; Muscle; Atrophy; CALCIUM-RELEASE CHANNEL; CARDIAC SARCOPLASMIC-RETICULUM; RYANODINE-RECEPTOR; ENDOPLASMIC-RETICULUM; S-NITROSYLATION; INOSITOL 1,4,5-TRISPHOSPHATE; CALMODULIN-BINDING; NITRIC-OXIDE; DIHYDROPYRIDINE RECEPTOR; MOLECULAR-CLONING;
D O I：
10.1007/s12079-018-0477-z
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The misbehaving attitude of Ca2+ signaling pathways could be the probable reason in many muscular disorders such as myopathies, systemic disorders like hypoxia, sepsis, cachexia, sarcopenia, heart failure, and dystrophy. The present review throws light upon the calcium flux regulating signaling channels like ryanodine receptor complex (RyR1), SERCA (Sarco-endoplasmic Reticulum Calcium ATPase), DHPR (Dihydropyridine Receptor) or Cav1.1 and Na+/Ca2+ exchange pump in detail and how remodelling of these channels contribute towards disturbed calcium homeostasis. Understanding these pathways will further provide an insight for establishing new therapeutic approaches for the prevention and treatment of muscle atrophy under stress conditions, targeting calcium ion channels and associated regulatory proteins.
引用
收藏
页码：645 / 659
页数：15
相关论文
共 151 条
  • [41] Sarcoplasmic reticulum function in slow- and fast-twitch skeletal muscles from mdx mice
    Divet, A
    Huchet-Cadiou, C
    [J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2002, 444 (05): : 634 - 643
  • [42] Interactions between dihydropyridine receptors and ryanodine receptors in striated muscle
    Dulhunty, AF
    Haarmann, CS
    Green, D
    Laver, DR
    Board, PG
    Casarotto, MG
    [J]. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2002, 79 (1-3) : 45 - 75
  • [43] Core skeletal muscle ryanodine receptor calcium release complex
    Dulhunty, Angela F.
    Wei-LaPierre, Lan
    Casarotto, Marco G.
    Beard, Nicole A.
    [J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2017, 44 (01): : 3 - 12
  • [44] RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice
    Durham, William J.
    Aracena-Parks, Paula
    Long, Cheng
    Rossi, Ann E.
    Goonasekera, Sanjeewa A.
    Boncompagni, Simona
    Galvan, Daniel L.
    Gilman, Charles P.
    Baker, Mariah R.
    Shirokova, Natalia
    Protasi, Feliciano
    Dirksen, Robert
    Hamilton, Susan L.
    [J]. CELL, 2008, 133 (01) : 53 - 65
  • [45] Slow calcium signals after tetanic electrical stimulation in skeletal myotubes
    Eltit, JM
    Hidalgo, J
    Liberona, JL
    Jaimovich, E
    [J]. BIOPHYSICAL JOURNAL, 2004, 86 (05) : 3042 - 3051
  • [46] CONDITIONS REQUIRED FOR CALCIUM-INDUCED RELEASE OF CALCIUM FROM SARCOPLASMIC-RETICULUM
    ENDO, M
    [J]. PROCEEDINGS OF THE JAPAN ACADEMY, 1975, 51 (06): : 467 - 472
  • [47] CALCIUM INDUCED RELEASE OF CALCIUM FROM SARCOPLASMIC RETICULUM OF SKINNED SKELETAL MUSCLE FIBRES
    ENDO, M
    TANAKA, M
    OGAWA, Y
    [J]. NATURE, 1970, 228 (5266) : 34 - &
  • [48] ENDO M, 1981, MECHANISM GATED CALC, P257
  • [49] Calcium-Induced Calcium Release in Skeletal Muscle
    Endo, Makoto
    [J]. PHYSIOLOGICAL REVIEWS, 2009, 89 (04) : 1153 - 1176
  • [50] The skeletal muscle calcium release channel:: Coupled O2 sensor and NO signaling functions
    Eu, JP
    Sun, JH
    Xu, L
    Stamler, JS
    Meissner, G
    [J]. CELL, 2000, 102 (04) : 499 - 509
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