Tumor-induced osteomalacia combined with acromegaly: A case report

被引：2

作者：

Li, Xiang ^{[1
]}

Ni, Xiaolin ^{[1
]}

Chai, Xiaofeng ^{[1
]}

Wang, Linjie ^{[1
]}

Jiang, Yan ^{[1
]}

Jing, Hongli ^{[2
]}

Huo, Li ^{[2
]}

Wu, Huanwen ^{[3
]}

Yao, Yong ^{[4
]}

Jin, Jin ^{[5
]}

Feng, Bin ^{[5
]}

Xia, Yu ^{[6
]}

Yu, Wei ^{[7
]}

Chi, Yue ^{[1
]}

Liu, Wei ^{[1
]}

Pang, Qianqian ^{[1
]}

Cui, Lijia ^{[1
]}

Jiajue, Ruizhi ^{[1
]}

Gong, Yiyi ^{[8
]}

Wang, Ou ^{[1
]}

Li, Mei ^{[1
]}

Xing, Xiaoping ^{[1
]}

Xia, Weibo ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Endocrinol,Natl Commiss Hlth, Key Lab Endocrinol,State Key Lab Complex Severe &, Shuaifuyuan 1,Wangfujing St, Beijing 100730, Peoples R China

[2] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Nucl Med, Beijing, Peoples R China

[3] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Pathol, Beijing, Peoples R China

[4] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Neurosurg, Beijing, Peoples R China

[5] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Orthoped Surg, Beijing, Peoples R China

[6] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Ultrasound Diag, Beijing, Peoples R China

[7] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Radiol, Beijing, Peoples R China

[8] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Med Res Ctr, State Key Lab Complex Severe & Rare Dis, Beijing, Peoples R China

来源：

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES | 2022年 / 1517卷 / 01期

基金：

中国国家自然科学基金;

关键词：

acromegaly; case report; octreoscan; phosphate; tumor-induced osteomalacia; PHOSPHATE;

D O I：

10.1111/nyas.14893

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Both acromegaly and tumor-induced osteomalacia (TIO) are rare diseases caused by an excess hormone secreted by neuroendocrine neoplasms, which are growth hormone (GH) and fibroblast growth factor 23 (FGF23), respectively. GH elevates phosphate reabsorption via the effect of insulin-like factor 1 (IGF-1), while FGF23 inhibits phosphate reabsorption and reduces serum phosphate level markedly. A patient who developed a typical acromegaly appearance but was accompanied with height loss and hypophosphatemia for 2 years visited our hospital. Laboratory investigations showed GH and IGF-1 hypersecretion, as well as hypophosphatemia caused by renal phosphate wasting. Magnetic resonance image revealed a pituitary somatotroph adenoma. Octreoscan scintigraphy also found a causative tumor on the right foot for hypophosphatemia. Then, he underwent resection of the tumor on the right foot. His serum phosphate returned to normal immediately but elevated gradually. Then, we removed the pituitary adenoma of the patient, and the GH and phosphate levels returned to the normal range. Here, we report the first case with acromegaly combined with TIO, the changing process of his phosphate concentration suggests an interesting concurrent effect of excess GH and FGF23 in this rare condition.

引用

页码：88 / 92

页数：5